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Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jäger R, Gorman AM, Samali A. Logue SE, et al. Among authors: legembre p. Nat Commun. 2018 Aug 15;9(1):3267. doi: 10.1038/s41467-018-05763-8. Nat Commun. 2018. PMID: 30111846 Free PMC article.
CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer.
Malleter M, Tauzin S, Bessede A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Collette Y, Vacher P, Legembre P. Malleter M, et al. Among authors: legembre p. Cancer Res. 2013 Nov 15;73(22):6711-21. doi: 10.1158/0008-5472.CAN-13-1794. Epub 2013 Sep 26. Cancer Res. 2013. PMID: 24072745
The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca(2+) flux from the endoplasmic reticulum to mitochondria.
Fouqué A, Lepvrier E, Debure L, Gouriou Y, Malleter M, Delcroix V, Ovize M, Ducret T, Li C, Hammadi M, Vacher P, Legembre P. Fouqué A, et al. Among authors: legembre p. Cell Death Differ. 2016 Oct;23(10):1702-16. doi: 10.1038/cdd.2016.61. Epub 2016 Jul 1. Cell Death Differ. 2016. PMID: 27367565 Free PMC article.
Chemotherapy with ceramide in TNBC.
Legembre P, Micheau O, Ségui B. Legembre P, et al. Oncoscience. 2015 Aug 21;2(10):817-8. doi: 10.18632/oncoscience.196. eCollection 2015. Oncoscience. 2015. PMID: 26682260 Free PMC article. No abstract available.
Disrupting the CD95-PLCγ1 interaction prevents Th17-driven inflammation.
Poissonnier A, Guégan JP, Nguyen HT, Best D, Levoin N, Kozlov G, Gehring K, Pineau R, Jouan F, Morere L, Martin S, Thomas M, Lazaro E, Douchet I, Ducret T, van de Weghe P, Blanco P, Jean M, Vacher P, Legembre P. Poissonnier A, et al. Among authors: legembre p. Nat Chem Biol. 2018 Dec;14(12):1079-1089. doi: 10.1038/s41589-018-0162-9. Epub 2018 Nov 14. Nat Chem Biol. 2018. PMID: 30429604
CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells.
Qadir AS, Guégan JP, Ginestier C, Chaibi A, Bessede A, Charafe-Jauffret E, Macario M, Lavoué V, Rouge TM, Law C, Vilker J, Wang H, Stroup E, Schipma MJ, Bridgeman B, Murmann AE, Ji Z, Legembre P, Peter ME. Qadir AS, et al. Among authors: legembre p. iScience. 2021 Oct 29;24(11):103348. doi: 10.1016/j.isci.2021.103348. eCollection 2021 Nov 19. iScience. 2021. PMID: 34816102 Free PMC article.
90 results