Lau K - Search Results

1

Long-term safety and efficacy of pegvaliase for the treatment of phenylketonuria in adults: combined phase 2 outcomes through PAL-003 extension study.

Longo N, Zori R, Wasserstein MP, Vockley J, Burton BK, Decker C, Li M, Lau K, Jiang J, Larimore K, Thomas JA. Longo N, et al. Among authors: lau k. Orphanet J Rare Dis. 2018 Jul 4;13(1):108. doi: 10.1186/s13023-018-0858-7. Orphanet J Rare Dis. 2018. PMID: 29973227 Free PMC article. Clinical Trial.

2

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials.

Gupta S, Lau K, Harding CO, Shepherd G, Boyer R, Atkinson JP, Knight V, Olbertz J, Larimore K, Gu Z, Li M, Rosen O, Zoog SJ, Weng HH, Schweighardt B. Gupta S, et al. Among authors: lau k. EBioMedicine. 2018 Nov;37:366-373. doi: 10.1016/j.ebiom.2018.10.038. Epub 2018 Oct 23. EBioMedicine. 2018. PMID: 30366815 Free PMC article. Clinical Trial.

3

Depletion of interfering IgG and IgM is critical to determine the role of IgE in pegvaliase-associated hypersensitivity.

Larimore K, Nguyen T, Badillo B, Lau K, Zori R, Shepherd G, Zoog SJ, Weng HH, Gupta S. Larimore K, et al. Among authors: lau k. J Immunol Methods. 2019 May;468:20-28. doi: 10.1016/j.jim.2019.03.004. Epub 2019 Mar 14. J Immunol Methods. 2019. PMID: 30880261

4

Pegvaliase for the treatment of phenylketonuria: Results of the phase 2 dose-finding studies with long-term follow-up.

Burton BK, Longo N, Vockley J, Grange DK, Harding CO, Decker C, Li M, Lau K, Rosen O, Larimore K, Thomas J; PAL-002 and PAL-004 Investigators. Burton BK, et al. Among authors: lau k. Mol Genet Metab. 2020 Aug;130(4):239-246. doi: 10.1016/j.ymgme.2020.06.006. Epub 2020 Jun 16. Mol Genet Metab. 2020. PMID: 32593547 Free article. Clinical Trial.

5

Achieving efficacy in subjects with sustained pegvaliase-neutralizing antibody responses.

Aryal M, Lau K, Boyer R, Zhou H, Abend J, Gu K, Olbertz J, Gupta S, Zoog S, Larimore K. Aryal M, et al. Among authors: lau k. Mol Genet Metab. 2021 Nov;134(3):235-242. doi: 10.1016/j.ymgme.2021.09.006. Epub 2021 Oct 4. Mol Genet Metab. 2021. PMID: 34716085 Free article. Clinical Trial.

6

Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers.

Martell L, Lau K, Mei M, Burnett V, Decker C, Foehr ED. Martell L, et al. Among authors: lau k. Orphanet J Rare Dis. 2011 Dec 16;6:84. doi: 10.1186/1750-1172-6-84. Orphanet J Rare Dis. 2011. PMID: 22176730 Free PMC article. Clinical Trial.

7

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A.

Long BR, Veron P, Kuranda K, Hardet R, Mitchell N, Hayes GM, Wong WY, Lau K, Li M, Hock MB, Zoog SJ, Vettermann C, Mingozzi F, Schweighardt B. Long BR, et al. Among authors: lau k. Mol Ther. 2021 Feb 3;29(2):597-610. doi: 10.1016/j.ymthe.2020.12.008. Epub 2020 Dec 10. Mol Ther. 2021. PMID: 33309883 Free PMC article.

8

Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial.

Schweighardt B, Tompkins T, Lau K, Jesaitis L, Qi Y, Musson DG, Farmer P, Haller C, Shaywitz AJ, Yang K, O'Neill CA. Schweighardt B, et al. Among authors: lau k. Clin Ther. 2015 May 1;37(5):1012-1021.e6. doi: 10.1016/j.clinthera.2014.11.005. Epub 2014 Dec 6. Clin Ther. 2015. PMID: 25487082 Clinical Trial.

9

Clinical immunogenicity outcomes from GENEr8-1, a phase 3 study of valoctocogene roxaparvovec, an AAV5-vectored gene therapy for hemophilia A.

Long BR, Robinson TM, Day JRS, Yu H, Lau K, Imtiaz U, Patton KS, de Hart G, Henshaw J, Agarwal S, Vettermann C, Zoog SJ, Gupta S. Long BR, et al. Among authors: lau k. Mol Ther. 2024 May 24:S1525-0016(24)00335-6. doi: 10.1016/j.ymthe.2024.05.033. Online ahead of print. Mol Ther. 2024. PMID: 38796703

10

Natural proteome diversity links aneuploidy tolerance to protein turnover.

Muenzner J, Trébulle P, Agostini F, Zauber H, Messner CB, Steger M, Kilian C, Lau K, Barthel N, Lehmann A, Textoris-Taube K, Caudal E, Egger AS, Amari F, De Chiara M, Demichev V, Gossmann TI, Mülleder M, Liti G, Schacherer J, Selbach M, Berman J, Ralser M. Muenzner J, et al. Among authors: lau k. Nature. 2024 May 22. doi: 10.1038/s41586-024-07442-9. Online ahead of print. Nature. 2024. PMID: 38778096

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