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Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Botuyan MV, Cui G, Drané P, Oliveira C, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G. Botuyan MV, et al. Among authors: parnandi n. Nat Struct Mol Biol. 2018 Jul;25(7):591-600. doi: 10.1038/s41594-018-0083-z. Epub 2018 Jul 2. Nat Struct Mol Biol. 2018. PMID: 29967538 Free PMC article.
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.
Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D. Drané P, et al. Among authors: parnandi n. Nature. 2017 Mar 9;543(7644):211-216. doi: 10.1038/nature21358. Epub 2017 Feb 27. Nature. 2017. PMID: 28241136 Free PMC article.
TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs.
Parnandi N, Rendo V, Cui G, Botuyan MV, Remisova M, Nguyen H, Drané P, Beroukhim R, Altmeyer M, Mer G, Chowdhury D. Parnandi N, et al. Mol Cell. 2021 Jun 17;81(12):2583-2595.e6. doi: 10.1016/j.molcel.2021.03.039. Epub 2021 May 6. Mol Cell. 2021. PMID: 33961797 Free PMC article.
Negative DNA supercoiling induces genome-wide Cas9 off-target activity.
Newton MD, Losito M, Smith QM, Parnandi N, Taylor BJ, Akcakaya P, Maresca M, van Eijk P, Reed SH, Boulton SJ, King GA, Cuomo ME, Rueda DS. Newton MD, et al. Among authors: parnandi n. Mol Cell. 2023 Oct 5;83(19):3533-3545.e5. doi: 10.1016/j.molcel.2023.09.008. Mol Cell. 2023. PMID: 37802026 Free article.