Eliciting unnatural immune responses by activating cryptic epitopes in viral antigens.
Lee YJ, Yu JE, Kim P, Lee JY, Cheong YC, Lee YJ, Chang J, Seong BL.
Lee YJ, et al. Among authors: chang j.
FASEB J. 2018 Sep;32(9):4658-4669. doi: 10.1096/fj.201701024RRR. Epub 2018 Mar 23.
FASEB J. 2018.
PMID: 29570395
Free PMC article.
By harnessing the antigen-processing machinery, our study shows a proof-of-principle for designer vaccines with increased efficacy and safety by either activating cryptic, or inactivating naturally occurring, epitopes of viral antigens.-Lee, Y. J., Yu, J. E., Kim, P …
By harnessing the antigen-processing machinery, our study shows a proof-of-principle for designer vaccines with increased efficacy and safet …