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EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter.
Schragenheim J, Bellner L, Cao J, Singh SP, Bamshad D, McClung JA, Maayan O, Meissner A, Grant I, Stier CT Jr, Abraham NG. Schragenheim J, et al. Among authors: mcclung ja. Prostaglandins Other Lipid Mediat. 2018 Jul;137:30-39. doi: 10.1016/j.prostaglandins.2018.05.008. Epub 2018 May 19. Prostaglandins Other Lipid Mediat. 2018. PMID: 29787809 Free PMC article.
Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats.
L'Abbate A, Neglia D, Vecoli C, Novelli M, Ottaviano V, Baldi S, Barsacchi R, Paolicchi A, Masiello P, Drummond GS, McClung JA, Abraham NG. L'Abbate A, et al. Among authors: mcclung ja. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3532-41. doi: 10.1152/ajpheart.00826.2007. Epub 2007 Sep 28. Am J Physiol Heart Circ Physiol. 2007. PMID: 17906103 Free article.
Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells.
Kim DH, Burgess AP, Li M, Tsenovoy PL, Addabbo F, McClung JA, Puri N, Abraham NG. Kim DH, et al. Among authors: mcclung ja. J Pharmacol Exp Ther. 2008 Jun;325(3):833-40. doi: 10.1124/jpet.107.135285. Epub 2008 Mar 11. J Pharmacol Exp Ther. 2008. PMID: 18334666
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