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Ac-Trp-DPhe(p-I)-Arg-Trp-NH2, a 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently.
Lensing CJ, Adank DN, Doering SR, Wilber SL, Andreasen A, Schaub JW, Xiang Z, Haskell-Luevano C. Lensing CJ, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1283-91. doi: 10.1021/acschemneuro.6b00156. Epub 2016 Jul 22. ACS Chem Neurosci. 2016. PMID: 27385405 Free PMC article.
A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.
Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C. Lensing CJ, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1262-1278. doi: 10.1021/acschemneuro.6b00399. Epub 2017 Feb 16. ACS Chem Neurosci. 2017. PMID: 28128928 Free PMC article.
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.
Ericson MD, Lensing CJ, Fleming KA, Schlasner KN, Doering SR, Haskell-Luevano C. Ericson MD, et al. Among authors: lensing cj. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2414-2435. doi: 10.1016/j.bbadis.2017.03.020. Epub 2017 Mar 29. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28363699 Free PMC article. Review.
Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.
Ericson MD, Singh A, Tala SR, Haslach EM, Dirain MLS, Schaub JW, Flores V, Eick N, Lensing CJ, Freeman KT, Smeester BA, Adank DN, Wilber SL, Speth R, Haskell-Luevano C. Ericson MD, et al. Among authors: lensing cj. J Med Chem. 2018 Apr 26;61(8):3738-3744. doi: 10.1021/acs.jmedchem.8b00251. Epub 2018 Apr 9. J Med Chem. 2018. PMID: 29578343 Free PMC article.
13 results