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Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L. Lu T, et al. Among authors: smans k. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2159-2164. doi: 10.1016/j.bmcl.2018.05.014. Epub 2018 May 8. Bioorg Med Chem Lett. 2018. PMID: 29779975
Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors.
Bijvelds MJC, Tresadern G, Hellemans A, Smans K, Nieuwenhuijze NDA, Meijsen KF, Bongartz JP, Ver Donck L, de Jonge HR, Schuurkes JAJ, De Maeyer JH. Bijvelds MJC, et al. Among authors: smans k. J Biol Chem. 2018 May 25;293(21):8173-8181. doi: 10.1074/jbc.RA118.002835. Epub 2018 Apr 13. J Biol Chem. 2018. PMID: 29653944 Free PMC article.
ATP-citrate lyase: a key player in cancer metabolism.
Zaidi N, Swinnen JV, Smans K. Zaidi N, et al. Among authors: smans k. Cancer Res. 2012 Aug 1;72(15):3709-14. doi: 10.1158/0008-5472.CAN-11-4112. Epub 2012 Jul 10. Cancer Res. 2012. PMID: 22787121 Review.
ATP-citrate lyase: a mini-review.
Chypre M, Zaidi N, Smans K. Chypre M, et al. Among authors: smans k. Biochem Biophys Res Commun. 2012 May 25;422(1):1-4. doi: 10.1016/j.bbrc.2012.04.144. Epub 2012 May 3. Biochem Biophys Res Commun. 2012. PMID: 22575446 Review.
De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.
Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, Vanderhoydonc F, Smans K, Waelkens E, Verhoeven G, Swinnen JV. Rysman E, et al. Among authors: smans k. Cancer Res. 2010 Oct 15;70(20):8117-26. doi: 10.1158/0008-5472.CAN-09-3871. Epub 2010 Sep 28. Cancer Res. 2010. PMID: 20876798
33 results