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Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.
Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK. Link VM, et al. Among authors: hoeksema ma. Cell. 2018 Jun 14;173(7):1796-1809.e17. doi: 10.1016/j.cell.2018.04.018. Epub 2018 May 17. Cell. 2018. PMID: 29779944 Free PMC article.
Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages.
van Wouw SAE, van den Berg M, El Ouraoui M, Meurs A, Kingma J, Ottenhoff R, Loix M, Hoeksema MA, Prange K, Pasterkamp G, Hendriks JJA, Bogie JFJ, van Klinken JB, Vaz FM, Jongejan A, de Winther MPJ, Zelcer N. van Wouw SAE, et al. Among authors: hoeksema ma. J Lipid Res. 2023 Feb;64(2):100325. doi: 10.1016/j.jlr.2022.100325. Epub 2022 Dec 31. J Lipid Res. 2023. PMID: 36592658 Free PMC article.
Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation.
Reilly NA, Sonnet F, Dekkers KF, Kwekkeboom JC, Sinke L, Hilt S, Suleiman HM, Hoeksema MA, Mei H, van Zwet EW, Everts B, Ioan-Facsinay A, Jukema JW, Heijmans BT. Reilly NA, et al. Among authors: hoeksema ma. iScience. 2024 Mar 12;27(4):109496. doi: 10.1016/j.isci.2024.109496. eCollection 2024 Apr 19. iScience. 2024. PMID: 38558932 Free PMC article.
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Hoeksema MA, et al. EMBO Mol Med. 2014 Sep;6(9):1124-32. doi: 10.15252/emmm.201404170. EMBO Mol Med. 2014. PMID: 25007801 Free PMC article.
Nature and nurture of tissue-specific macrophage phenotypes.
Hoeksema MA, Glass CK. Hoeksema MA, et al. Atherosclerosis. 2019 Feb;281:159-167. doi: 10.1016/j.atherosclerosis.2018.10.005. Epub 2018 Oct 6. Atherosclerosis. 2019. PMID: 30343819 Free PMC article. Review.
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate.
Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. Weiss RJ, et al. Among authors: hoeksema ma. Nat Chem Biol. 2021 Jun;17(6):684-692. doi: 10.1038/s41589-021-00776-9. Epub 2021 Apr 12. Nat Chem Biol. 2021. PMID: 33846619 Free PMC article.
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