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CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.
Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A, Clark W, McGhee EJ, Wang J, Escorcio-Correia M, Zollinger R, Roshani R, Drew L, Rishi L, Arkell R, Evans TRJ, Nixon C, Jodrell DI, Wilkinson RW, Biankin AV, Barry ST, Balkwill FR, Sansom OJ. Candido JB, et al. Among authors: mcghee ej. Cell Rep. 2018 May 1;23(5):1448-1460. doi: 10.1016/j.celrep.2018.03.131. Cell Rep. 2018. PMID: 29719257 Free PMC article.
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ. Miller BW, et al. EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827. EMBO Mol Med. 2015. PMID: 26077591 Free PMC article.
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.
Timpson P, McGhee EJ, Morton JP, von Kriegsheim A, Schwarz JP, Karim SA, Doyle B, Quinn JA, Carragher NO, Edward M, Olson MF, Frame MC, Brunton VG, Sansom OJ, Anderson KI. Timpson P, et al. Among authors: mcghee ej. Cancer Res. 2011 Feb 1;71(3):747-57. doi: 10.1158/0008-5472.CAN-10-2267. Epub 2011 Jan 25. Cancer Res. 2011. PMID: 21266354 Free PMC article.
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.
Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P. Erami Z, et al. Among authors: mcghee ej. Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24. Cell Rep. 2016. PMID: 26725115 Free PMC article.
Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.
Radulescu S, Brookes MJ, Salgueiro P, Ridgway RA, McGhee E, Anderson K, Ford SJ, Stones DH, Iqbal TH, Tselepis C, Sansom OJ. Radulescu S, et al. Cell Rep. 2012 Aug 30;2(2):270-82. doi: 10.1016/j.celrep.2012.07.003. Epub 2012 Aug 9. Cell Rep. 2012. PMID: 22884366 Free article.
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.
Nobis M, McGhee EJ, Morton JP, Schwarz JP, Karim SA, Quinn J, Edward M, Campbell AD, McGarry LC, Evans TR, Brunton VG, Frame MC, Carragher NO, Wang Y, Sansom OJ, Timpson P, Anderson KI. Nobis M, et al. Among authors: mcghee ej. Cancer Res. 2013 Aug 1;73(15):4674-86. doi: 10.1158/0008-5472.CAN-12-4545. Epub 2013 Jun 7. Cancer Res. 2013. PMID: 23749641 Free article.
The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.
Johnsson AE, Dai Y, Nobis M, Baker MJ, McGhee EJ, Walker S, Schwarz JP, Kadir S, Morton JP, Myant KB, Huels DJ, Segonds-Pichon A, Sansom OJ, Anderson KI, Timpson P, Welch HCE. Johnsson AE, et al. Among authors: mcghee ej. Cell Rep. 2014 Mar 27;6(6):1153-1164. doi: 10.1016/j.celrep.2014.02.024. Epub 2014 Mar 13. Cell Rep. 2014. PMID: 24630994 Free PMC article.
38 results