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Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Consortium Study.
Kieran MW, Packer RJ, Onar A, Blaney SM, Phillips P, Pollack IF, Geyer JR, Gururangan S, Banerjee A, Goldman S, Turner CD, Belasco JB, Broniscer A, Zhu Y, Frank E, Kirschmeier P, Statkevich P, Yver A, Boyett JM, Kun LE. Kieran MW, et al. J Clin Oncol. 2007 Jul 20;25(21):3137-43. doi: 10.1200/JCO.2006.09.4243. J Clin Oncol. 2007. PMID: 17634493 Clinical Trial.
New approaches to progeria.
Kieran MW, Gordon L, Kleinman M. Kieran MW, et al. Pediatrics. 2007 Oct;120(4):834-41. doi: 10.1542/peds.2007-1356. Pediatrics. 2007. PMID: 17908771 Review.
Hutchinson-Gilford progeria is a skeletal dysplasia.
Gordon CM, Gordon LB, Snyder BD, Nazarian A, Quinn N, Huh S, Giobbie-Hurder A, Neuberg D, Cleveland R, Kleinman M, Miller DT, Kieran MW. Gordon CM, et al. Among authors: kieran mw. J Bone Miner Res. 2011 Jul;26(7):1670-9. doi: 10.1002/jbmr.392. J Bone Miner Res. 2011. PMID: 21445982 Free PMC article.
Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome.
Gerhard-Herman M, Smoot LB, Wake N, Kieran MW, Kleinman ME, Miller DT, Schwartzman A, Giobbie-Hurder A, Neuberg D, Gordon LB. Gerhard-Herman M, et al. Among authors: kieran mw. Hypertension. 2012 Jan;59(1):92-7. doi: 10.1161/HYPERTENSIONAHA.111.180919. Epub 2011 Nov 14. Hypertension. 2012. PMID: 22083160 Free PMC article. Clinical Trial.
Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome.
Gordon LB, Kleinman ME, Miller DT, Neuberg DS, Giobbie-Hurder A, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland R, Snyder BD, Fligor B, Bishop WR, Statkevich P, Regen A, Sonis A, Riley S, Ploski C, Correia A, Quinn N, Ullrich NJ, Nazarian A, Liang MG, Huh SY, Schwartzman A, Kieran MW. Gordon LB, et al. Among authors: kieran mw. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16666-71. doi: 10.1073/pnas.1202529109. Epub 2012 Sep 24. Proc Natl Acad Sci U S A. 2012. PMID: 23012407 Free PMC article. Clinical Trial.
273 results