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A manually annotated Actinidia chinensis var. chinensis (kiwifruit) genome highlights the challenges associated with draft genomes and gene prediction in plants.
Pilkington SM, Crowhurst R, Hilario E, Nardozza S, Fraser L, Peng Y, Gunaseelan K, Simpson R, Tahir J, Deroles SC, Templeton K, Luo Z, Davy M, Cheng C, McNeilage M, Scaglione D, Liu Y, Zhang Q, Datson P, De Silva N, Gardiner SE, Bassett H, Chagné D, McCallum J, Dzierzon H, Deng C, Wang YY, Barron L, Manako K, Bowen J, Foster TM, Erridge ZA, Tiffin H, Waite CN, Davies KM, Grierson EP, Laing WA, Kirk R, Chen X, Wood M, Montefiori M, Brummell DA, Schwinn KE, Catanach A, Fullerton C, Li D, Meiyalaghan S, Nieuwenhuizen N, Read N, Prakash R, Hunter D, Zhang H, McKenzie M, Knäbel M, Harris A, Allan AC, Gleave A, Chen A, Janssen BJ, Plunkett B, Ampomah-Dwamena C, Voogd C, Leif D, Lafferty D, Souleyre EJF, Varkonyi-Gasic E, Gambi F, Hanley J, Yao JL, Cheung J, David KM, Warren B, Marsh K, Snowden KC, Lin-Wang K, Brian L, Martinez-Sanchez M, Wang M, Ileperuma N, Macnee N, Campin R, McAtee P, Drummond RSM, Espley RV, Ireland HS, Wu R, Atkinson RG, Karunairetnam S, Bulley S, Chunkath S, Hanley Z, Storey R, Thrimawithana AH, Thomson S, David C, Testolin R, Huang H, Hellens RP, Schaffer RJ. Pilkington SM, et al. Among authors: leif d. BMC Genomics. 2018 Apr 16;19(1):257. doi: 10.1186/s12864-018-4656-3. BMC Genomics. 2018. PMID: 29661190 Free PMC article.
A comparative study of different antiviral treatment protocols in HCV related cryoglobulinemic vasculitis.
Allam WR, Hegazy MT, Hussein MA, Zoheir N, Quartuccio L, El-Khamisy SF, Ragab G. Allam WR, et al. Sci Rep. 2024 May 23;14(1):11840. doi: 10.1038/s41598-024-60490-z. Sci Rep. 2024. PMID: 38782988
We compared, head-to-head, three antiviral protocols for HCV-MCV treatment As regards the treatment response and relapse, levels of BAFF and APRIL among pegylated interferon alpha-based and free regimens (Sofosbuvir + Ribavirin; SOF-RIBA, Sofosbuvir + Daclatasvir; S …
We compared, head-to-head, three antiviral protocols for HCV-MCV treatment As regards the treatment response and relapse, levels of BAFF and …
Unusual presentation of ocular surface squamous neoplasia in a young healthy patient: A case report.
Knutsson KA, Tombolini B, Paganoni G, Rama P, Bandello F. Knutsson KA, et al. Eur J Ophthalmol. 2024 May 23:11206721241256150. doi: 10.1177/11206721241256150. Online ahead of print. Eur J Ophthalmol. 2024. PMID: 38780357
DISCUSSION: The present report described an atypical presentation of HPV-related OSSN due to its unusual morphology, young age of onset and absence of associated comorbidity. CONCLUSION: Conservative treatment with topical interferon-alpha 2b could be used to treat …
DISCUSSION: The present report described an atypical presentation of HPV-related OSSN due to its unusual morphology, young age of onset and …
Predictive role of early treatment dynamics of HBV RNA and HBcrAg for HBeAg seroconversion in children with chronic hepatitis B.
Lai X, OuYang W, Li S, Qiu J, Zhang H, Jiang T, Qin X, Tang L, Gu Y, Yao Z, Peng S. Lai X, et al. J Med Virol. 2024 May;96(5):e29670. doi: 10.1002/jmv.29670. J Med Virol. 2024. PMID: 38773810
Treatment-naive HBeAg-positive CHB children who admitted to the Liver Disease Center of Hunan Children's Hospital between April 2021 and September 2022 and received treatment with the combined entecavir and interferon-alpha treatment were recruited. Serum HBV RNA an …
Treatment-naive HBeAg-positive CHB children who admitted to the Liver Disease Center of Hunan Children's Hospital between April 2021 and Sep …
Exploring the immune characteristions of CRKP pneumonia at single-cell level.
Sun Y, Chen F, Ma H, Wang D, Wang D, Zhang J, Jiang Z, Xia R, Tian T, Zhang W. Sun Y, et al. Comput Biol Med. 2024 May 11;177:108574. doi: 10.1016/j.compbiomed.2024.108574. Online ahead of print. Comput Biol Med. 2024. PMID: 38772102
Overall, most immune cells in CRKP patients exhibited a robust interferon-alpha response and inflammatory reaction compared to healthy controls, mirroring observations in COVID-19 patients. ...
Overall, most immune cells in CRKP patients exhibited a robust interferon-alpha response and inflammatory reaction compared to …
Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments.
Zhao F, Zhao J, Wei K, Jiang P, Shi Y, Chang C, Zheng Y, Shan Y, Li Y, He B, Zhou M, Liu J, Li L, Guo S, He D. Zhao F, et al. Immunotargets Ther. 2024 May 16;13:259-271. doi: 10.2147/ITT.S458800. eCollection 2024. Immunotargets Ther. 2024. PMID: 38770264 Free PMC article. Review.
It details recent advancements in RNA interference that modulate key factors including keratinocyte proliferation (Fibroblast Growth Factor Receptor 2, FGFR2), apoptosis (Interferon Alpha Inducible Protein 6, G1P3), differentiation (Grainyhead Like Transcription Fac …
It details recent advancements in RNA interference that modulate key factors including keratinocyte proliferation (Fibroblast Growth Factor …
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo.
Patel R, Cooper DE, Kadakia KT, Allen A, Duan L, Luo L, Williams NT, Liu X, Locasale JW, Kirsch DG. Patel R, et al. Commun Biol. 2024 May 20;7(1):608. doi: 10.1038/s42003-024-06262-x. Commun Biol. 2024. PMID: 38769385 Free PMC article.
Finally, Gls1-deficient sarcomas post-RT elevate levels of proteins involved in natural killer cell and interferon alpha/gamma responses, suggesting a possible role of innate immunity in the radiosensitization of Gls1-deficient sarcomas. ...
Finally, Gls1-deficient sarcomas post-RT elevate levels of proteins involved in natural killer cell and interferon alpha/gamma …
A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection.
Ciesla J, Huang KL, Wagner EJ, Munger J. Ciesla J, et al. PLoS Pathog. 2024 May 20;20(5):e1012058. doi: 10.1371/journal.ppat.1012058. Online ahead of print. PLoS Pathog. 2024. PMID: 38768227 Free article.
Our results indicate that UL26 prevents STAT phosphorylation during infection and antagonizes transcriptional activation induced by either interferon alpha (IFNA) or tumor necrosis factor alpha (TNFalpha). Additionally, we find that the inactivation of PIAS1 sensiti …
Our results indicate that UL26 prevents STAT phosphorylation during infection and antagonizes transcriptional activation induced by either …
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice.
Syed F, Ballew O, Lee CC, Rana J, Krishnan P, Castela A, Weaver SA, Chalasani NS, Thomaidou SF, Demine S, Chang G, Coomans de Brachène A, Alvelos MI, Marselli L, Orr K, Felton JL, Liu J, Marchetti P, Zaldumbide A, Scheuner D, Eizirik DL, Evans-Molina C. Syed F, et al. bioRxiv [Preprint]. 2024 May 9:2024.03.20.585925. doi: 10.1101/2024.03.20.585925. bioRxiv. 2024. PMID: 38766166 Free PMC article. Preprint.
Tyrosine protein-kinase 2 (TYK2), a member of the Janus kinase family, mediates inflammatory signaling through multiple cytokines, including interferon-alpha (IFNalpha), interleukin (IL)-12, and IL-23. Missense mutations in TYK2 are associated with protection agains …
Tyrosine protein-kinase 2 (TYK2), a member of the Janus kinase family, mediates inflammatory signaling through multiple cytokines, including …
40,310 results
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