Stich A - Search Results

1

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

Giroud M, Dietzel U, Anselm L, Banner D, Kuglstatter A, Benz J, Blanc JB, Gaufreteau D, Liu H, Lin X, Stich A, Kuhn B, Schuler F, Kaiser M, Brun R, Schirmeister T, Kisker C, Diederich F, Haap W. Giroud M, et al. Among authors: stich a. J Med Chem. 2018 Apr 26;61(8):3350-3369. doi: 10.1021/acs.jmedchem.7b01869. Epub 2018 Apr 13. J Med Chem. 2018. PMID: 29590750

2

Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.

Hiltensperger G, Jones NG, Niedermeier S, Stich A, Kaiser M, Jung J, Puhl S, Damme A, Braunschweig H, Meinel L, Engstler M, Holzgrabe U. Hiltensperger G, et al. Among authors: stich a. J Med Chem. 2012 Mar 22;55(6):2538-48. doi: 10.1021/jm101439s. Epub 2012 Mar 12. J Med Chem. 2012. PMID: 22376072

3

Bistacrines as potential antitrypanosomal agents.

Schmidt I, Göllner S, Fuß A, Stich A, Kucharski A, Schirmeister T, Katzowitsch E, Bruhn H, Miliu A, Krauth-Siegel RL, Holzgrabe U. Schmidt I, et al. Among authors: stich a. Bioorg Med Chem. 2017 Aug 15;25(16):4526-4531. doi: 10.1016/j.bmc.2017.06.051. Epub 2017 Jul 1. Bioorg Med Chem. 2017. PMID: 28698054

4

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T. Breuning A, et al. Among authors: stich a. J Med Chem. 2010 Mar 11;53(5):1951-63. doi: 10.1021/jm900946n. J Med Chem. 2010. PMID: 20131843

5

Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.

Waag T, Gelhaus C, Rath J, Stich A, Leippe M, Schirmeister T. Waag T, et al. Among authors: stich a. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. doi: 10.1016/j.bmcl.2010.07.062. Epub 2010 Aug 6. Bioorg Med Chem Lett. 2010. PMID: 20692829

6

Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei.

Ehmke V, Heindl C, Rottmann M, Freymond C, Schweizer WB, Brun R, Stich A, Schirmeister T, Diederich F. Ehmke V, et al. Among authors: stich a. ChemMedChem. 2011 Feb 7;6(2):273-8. doi: 10.1002/cmdc.201000449. Epub 2010 Nov 25. ChemMedChem. 2011. PMID: 21275051 Free PMC article.

7

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Vicik R, et al. Among authors: stich a. Bioorg Med Chem Lett. 2006 May 15;16(10):2753-7. doi: 10.1016/j.bmcl.2006.02.026. Epub 2006 Mar 3. Bioorg Med Chem Lett. 2006. PMID: 16516467

8

QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids.

Bringmann G, Bischof SK, Müller S, Gulder T, Winter C, Stich A, Moll H, Kaiser M, Brun R, Dreher J, Baumann K. Bringmann G, et al. Among authors: stich a. Eur J Med Chem. 2010 Nov;45(11):5370-83. doi: 10.1016/j.ejmech.2010.08.062. Epub 2010 Sep 17. Eur J Med Chem. 2010. PMID: 20850207

9

Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius.

Xu M, Bruhn T, Hertlein B, Brun R, Stich A, Wu J, Bringmann G. Xu M, et al. Among authors: stich a. Chemistry. 2010 Apr 12;16(14):4206-16. doi: 10.1002/chem.200903247. Chemistry. 2010. PMID: 20235249

10

Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.

Altenkämper M, Bechem B, Perruchon J, Heinrich S, Mädel A, Ortmann R, Dahse HM, Freunscht E, Wang Y, Rath J, Stich A, Hitzler M, Chiba P, Lanzer M, Schlitzer M. Altenkämper M, et al. Among authors: stich a. Bioorg Med Chem. 2009 Nov 15;17(22):7690-7. doi: 10.1016/j.bmc.2009.09.043. Epub 2009 Sep 25. Bioorg Med Chem. 2009. PMID: 19819706

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