Young GT - Search Results

1

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.

Cho LT, Alexandrou AJ, Torella R, Knafels J, Hobbs J, Taylor T, Loucif A, Konopacka A, Bell S, Stevens EB, Pandit J, Horst R, Withka JM, Pryde DC, Liu S, Young GT. Cho LT, et al. Among authors: young gt. Structure. 2018 Apr 3;26(4):533-544.e3. doi: 10.1016/j.str.2018.02.017. Epub 2018 Mar 22. Structure. 2018. PMID: 29576321 Free article.

2

Identification of Positive Allosteric Modulators of Glycine Receptors from a High-Throughput Screen Using a Fluorescent Membrane Potential Assay.

Stead C, Brown A, Adams C, Nickolls SJ, Young G, Kammonen J, Pryde D, Cawkill D. Stead C, et al. J Biomol Screen. 2016 Dec;21(10):1042-1053. doi: 10.1177/1087057116657779. Epub 2016 Jul 11. J Biomol Screen. 2016. PMID: 27412533

3

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

Young GT, Gutteridge A, Fox H, Wilbrey AL, Cao L, Cho LT, Brown AR, Benn CL, Kammonen LR, Friedman JH, Bictash M, Whiting P, Bilsland JG, Stevens EB. Young GT, et al. Mol Ther. 2014 Aug;22(8):1530-1543. doi: 10.1038/mt.2014.86. Epub 2014 May 15. Mol Ther. 2014. PMID: 24832007 Free PMC article.

4

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB. Cao L, et al. Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653. Sci Transl Med. 2016. PMID: 27099175 Clinical Trial.

5

HCN2 ion channels play a central role in inflammatory and neuropathic pain.

Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA. Emery EC, et al. Among authors: young gt. Science. 2011 Sep 9;333(6048):1462-6. doi: 10.1126/science.1206243. Science. 2011. PMID: 21903816

6

A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV).

Shaikh SS, Chen YC, Halsall SA, Nahorski MS, Omoto K, Young GT, Phelan A, Woods CG. Shaikh SS, et al. Among authors: young gt. Hum Mutat. 2017 Jan;38(1):55-63. doi: 10.1002/humu.23123. Epub 2016 Nov 26. Hum Mutat. 2017. PMID: 27676246 Free PMC article.

7

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Na_v1.7.

He W, Young GT, Zhang B, Cox PJ, Cho LT, John S, Paciga SA, Wood LS, Danziger N, Scollen S, Vangjeli C. He W, et al. Among authors: young gt. BMC Med Genet. 2018 Jul 23;19(1):124. doi: 10.1186/s12881-018-0643-4. BMC Med Genet. 2018. PMID: 30037327 Free PMC article.

8

HCN2 ion channels: an emerging role as the pacemakers of pain.

Emery EC, Young GT, McNaughton PA. Emery EC, et al. Among authors: young gt. Trends Pharmacol Sci. 2012 Aug;33(8):456-63. doi: 10.1016/j.tips.2012.04.004. Epub 2012 May 19. Trends Pharmacol Sci. 2012. PMID: 22613784 Review.

9

Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.

Young GT, Emery EC, Mooney ER, Tsantoulas C, McNaughton PA. Young GT, et al. Pain. 2014 Sep;155(9):1708-1719. doi: 10.1016/j.pain.2014.05.021. Epub 2014 May 23. Pain. 2014. PMID: 24861581

10

Unraveling a model of TCL/RhoJ allosterism using TC10 reverse chimeras.

Florke RR, Young GT, Hamann MJ. Florke RR, et al. Among authors: young gt. Small GTPases. 2020 Mar;11(2):138-145. doi: 10.1080/21541248.2017.1347599. Epub 2017 Oct 3. Small GTPases. 2020. PMID: 28696829 Free PMC article.

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