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Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding.
Parmar A, Iyer A, Prior SH, Lloyd DG, Leng Goh ET, Vincent CS, Palmai-Pallag T, Bachrati CZ, Breukink E, Madder A, Lakshminarayanan R, Taylor EJ, Singh I. Parmar A, et al. Among authors: lakshminarayanan r. Chem Sci. 2017 Dec 1;8(12):8183-8192. doi: 10.1039/c7sc03241b. Epub 2017 Oct 5. Chem Sci. 2017. PMID: 29568465 Free PMC article.
Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo.
Parmar A, Lakshminarayanan R, Iyer A, Mayandi V, Leng Goh ET, Lloyd DG, Chalasani MLS, Verma NK, Prior SH, Beuerman RW, Madder A, Taylor EJ, Singh I. Parmar A, et al. Among authors: lakshminarayanan r. J Med Chem. 2018 Mar 8;61(5):2009-2017. doi: 10.1021/acs.jmedchem.7b01634. Epub 2018 Feb 15. J Med Chem. 2018. PMID: 29363971
Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA).
Malkawi R, Iyer A, Parmar A, Lloyd DG, Leng Goh ET, Taylor EJ, Sarmad S, Madder A, Lakshminarayanan R, Singh I. Malkawi R, et al. Among authors: lakshminarayanan r. Pharmaceutics. 2018 Oct 11;10(4):183. doi: 10.3390/pharmaceutics10040183. Pharmaceutics. 2018. PMID: 30314324 Free PMC article.
Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections.
Koh JJ, Lin S, Aung TT, Lim F, Zou H, Bai Y, Li J, Lin H, Pang LM, Koh WL, Salleh SM, Lakshminarayanan R, Zhou L, Qiu S, Pervushin K, Verma C, Tan DT, Cao D, Liu S, Beuerman RW. Koh JJ, et al. Among authors: lakshminarayanan r. J Med Chem. 2015 Jan 22;58(2):739-52. doi: 10.1021/jm501285x. Epub 2014 Dec 17. J Med Chem. 2015. PMID: 25474410
The structural parameters for antimicrobial activity, human epithelial cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminal region.
Zhou L, Liu SP, Chen LY, Li J, Ong LB, Guo L, Wohland T, Tang CC, Lakshminarayanan R, Mavinahalli J, Verma C, Beuerman RW. Zhou L, et al. Among authors: lakshminarayanan r. Amino Acids. 2011 Jan;40(1):123-33. doi: 10.1007/s00726-010-0565-8. Epub 2010 Apr 17. Amino Acids. 2011. PMID: 20397033
140 results