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A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan.
PLoS Pathog. 2018.
PMID: 29338055
Free PMC article.
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.
Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D.
Lau A, et al. Among authors: gapeshina h.
EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588.
EMBO Mol Med. 2015.
PMID: 25661904
Free PMC article.
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Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency.
Daude N, Wohlgemuth S, Brown R, Pitstick R, Gapeshina H, Yang J, Carlson GA, Westaway D.
Daude N, et al. Among authors: gapeshina h.
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9035-40. doi: 10.1073/pnas.1202130109. Epub 2012 May 22.
Proc Natl Acad Sci U S A. 2012.
PMID: 22619325
Free PMC article.
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Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia.
Daude N, Gapeshina H, Dong B, Winship I, Westaway D.
Daude N, et al. Among authors: gapeshina h.
Prion. 2015;9(5):376-93. doi: 10.1080/19336896.2015.1105432.
Prion. 2015.
PMID: 26516793
Free PMC article.
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The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.
Eskandari-Sedighi G, Daude N, Gapeshina H, Sanders DW, Kamali-Jamil R, Yang J, Shi B, Wille H, Ghetti B, Diamond MI, Janus C, Westaway D.
Eskandari-Sedighi G, et al. Among authors: gapeshina h.
Mol Neurodegener. 2017 Oct 4;12(1):72. doi: 10.1186/s13024-017-0215-7.
Mol Neurodegener. 2017.
PMID: 28978354
Free PMC article.
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A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.
Daude N, Lee I, Kim TK, Janus C, Glaves JP, Gapeshina H, Yang J, Sykes BD, Carlson GA, Hood LE, Westaway D.
Daude N, et al. Among authors: gapeshina h.
PLoS One. 2016 Feb 19;11(2):e0149410. doi: 10.1371/journal.pone.0149410. eCollection 2016.
PLoS One. 2016.
PMID: 26894278
Free PMC article.
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