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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF. Hyer ML, et al. Among authors: yang y. Nat Med. 2018 Feb;24(2):186-193. doi: 10.1038/nm.4474. Epub 2018 Jan 15. Nat Med. 2018. PMID: 29334375
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Kupperman E, Lee EC, Cao Y, Bannerman B, Fitzgerald M, Berger A, Yu J, Yang Y, Hales P, Bruzzese F, Liu J, Blank J, Garcia K, Tsu C, Dick L, Fleming P, Yu L, Manfredi M, Rolfe M, Bolen J. Kupperman E, et al. Among authors: yang y. Cancer Res. 2010 Mar 1;70(5):1970-80. doi: 10.1158/0008-5472.CAN-09-2766. Epub 2010 Feb 16. Cancer Res. 2010. PMID: 20160034
KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.
Chattopadhyay N, Berger AJ, Koenig E, Bannerman B, Garnsey J, Bernard H, Hales P, Maldonado Lopez A, Yang Y, Donelan J, Jordan K, Tirrell S, Stringer B, Xia C, Hather G, Galvin K, Manfredi M, Rhodes N, Amidon B. Chattopadhyay N, et al. Among authors: yang y. PLoS One. 2015 Dec 28;10(12):e0144825. doi: 10.1371/journal.pone.0144825. eCollection 2015. PLoS One. 2015. PMID: 26709701 Free PMC article.
Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors.
Huang SC, Adhikari S, Brownell JE, Calderwood EF, Chouitar J, D'Amore NR, England DB, Foley K, Harrison SJ, LeRoy PJ, Lok D, Lublinsky A, Ma LT, Menon S, Yang Y, Zhang J, Gould AE. Huang SC, et al. Among authors: yang y. Bioorg Med Chem. 2020 Oct 1;28(19):115681. doi: 10.1016/j.bmc.2020.115681. Epub 2020 Aug 4. Bioorg Med Chem. 2020. PMID: 32912429 Free article.
Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer.
Carol H, Boehm I, Reynolds CP, Kang MH, Maris JM, Morton CL, Gorlick R, Kolb EA, Keir ST, Wu J, Wozniak AE, Yang Y, Manfredi M, Ecsedy J, Wang J, Neale G, Houghton PJ, Smith MA, Lock RB. Carol H, et al. Among authors: yang y. Cancer Chemother Pharmacol. 2011 Nov;68(5):1291-304. doi: 10.1007/s00280-011-1618-8. Epub 2011 Mar 30. Cancer Chemother Pharmacol. 2011. PMID: 21448591 Free PMC article.
SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties.
Warren MC, Matissek S, Rausch M, Panduro M, Hall RJ, Dulak A, Brennan D, Das Yekkirala S, Koseoglu S, Masia R, Yang Y, Reddy N, Prenovitz R, Strand J, Zaidi T, Devereaux E, Foissac CJ, Stagg J, Lee BH, Holland P, Palombella VJ, Lake AC. Warren MC, et al. Among authors: yang y. Immunohorizons. 2023 May 1;7(5):366-379. doi: 10.4049/immunohorizons.2200089. Immunohorizons. 2023. PMID: 37219538 Free PMC article.
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