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Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.
Leong TL, Gayevskiy V, Steinfort DP, De Massy MR, Gonzalez-Rajal A, Marini KD, Stone E, Chin V, Havryk A, Plit M, Irving LB, Jennings BR, McCloy RA, Jayasekara WSN, Alamgeer M, Boolell V, Field A, Russell PA, Kumar B, Gough DJ, Szczepny A, Ganju V, Rossello FJ, Cain JE, Papenfuss AT, Asselin-Labat ML, Cowley MJ, Watkins DN. Leong TL, et al. Among authors: gough dj. Oncogene. 2019 Mar;38(10):1661-1675. doi: 10.1038/s41388-018-0536-1. Epub 2018 Oct 22. Oncogene. 2019. PMID: 30348992 Free PMC article.
Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype.
Vaghjiani VG, Cochrane CR, Jayasekara WSN, Chong WC, Szczepny A, Kumar B, Martelotto LG, McCaw A, Carey K, Kansara M, Thomas DM, Walkley C, Mudge S, Gough DJ, Downie PA, Peacock CD, Matsui W, Watkins DN, Cain JE. Vaghjiani VG, et al. Among authors: gough dj. Oncogene. 2023 Nov;42(47):3529-3541. doi: 10.1038/s41388-023-02864-7. Epub 2023 Oct 16. Oncogene. 2023. PMID: 37845394 Free PMC article.
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
Cochrane CR, Vaghjiani V, Szczepny A, Jayasekara WSN, Gonzalez-Rajal A, Kikuchi K, McCaughan GW, Burgess A, Gough DJ, Watkins DN, Cain JE. Cochrane CR, et al. Among authors: gough dj. J Clin Invest. 2020 Aug 3;130(8):4006-4018. doi: 10.1172/JCI132513. J Clin Invest. 2020. PMID: 32568216 Free PMC article.
MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, Firestein R. Sooraj D, et al. Among authors: gough dj. Mol Cell. 2022 Jan 6;82(1):123-139.e7. doi: 10.1016/j.molcel.2021.11.015. Epub 2021 Dec 14. Mol Cell. 2022. PMID: 34910943 Free article.
45 results