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Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle.
Wasson CW, Morgan EL, Müller M, Ross RL, Hartley M, Roberts S, Macdonald A. Wasson CW, et al. Among authors: roberts s. Oncotarget. 2017 Oct 6;8(61):103581-103600. doi: 10.18632/oncotarget.21658. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262586 Free PMC article.
STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.
Morgan EL, Wasson CW, Hanson L, Kealy D, Pentland I, McGuire V, Scarpini C, Coleman N, Arthur JSC, Parish JL, Roberts S, Macdonald A. Morgan EL, et al. Among authors: roberts s. PLoS Pathog. 2018 Apr 9;14(4):e1006975. doi: 10.1371/journal.ppat.1006975. eCollection 2018 Apr. PLoS Pathog. 2018. PMID: 29630659 Free PMC article.
Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma.
Bryant J, Batis N, Franke AC, Clancey G, Hartley M, Ryan G, Brooks J, Southam AD, Barnes N, Parish J, Roberts S, Khanim F, Spruce R, Mehanna H. Bryant J, et al. Among authors: roberts s. Oncotarget. 2019 Aug 27;10(50):5229-5244. doi: 10.18632/oncotarget.27156. eCollection 2019 Aug 27. Oncotarget. 2019. PMID: 31497252 Free PMC article.
Human papillomavirus type 1 E1^E4 protein is a potent inhibitor of the serine-arginine (SR) protein kinase SRPK1 and inhibits phosphorylation of host SR proteins and of the viral transcription and replication regulator E2.
Prescott EL, Brimacombe CL, Hartley M, Bell I, Graham S, Roberts S. Prescott EL, et al. Among authors: roberts s. J Virol. 2014 Nov;88(21):12599-611. doi: 10.1128/JVI.02029-14. Epub 2014 Aug 20. J Virol. 2014. PMID: 25142587 Free PMC article.
Disruption of CTCF-YY1-dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription.
Pentland I, Campos-León K, Cotic M, Davies KJ, Wood CD, Groves IJ, Burley M, Coleman N, Stockton JD, Noyvert B, Beggs AD, West MJ, Roberts S, Parish JL. Pentland I, et al. Among authors: roberts s. PLoS Biol. 2018 Oct 25;16(10):e2005752. doi: 10.1371/journal.pbio.2005752. eCollection 2018 Oct. PLoS Biol. 2018. PMID: 30359362 Free PMC article.
A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK-cyclin complexes and G2/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L1 capsid protein expression.
Knight GL, Pugh AG, Yates E, Bell I, Wilson R, Moody CA, Laimins LA, Roberts S. Knight GL, et al. Among authors: roberts s. Virology. 2011 Mar 30;412(1):196-210. doi: 10.1016/j.virol.2011.01.007. Epub 2011 Jan 31. Virology. 2011. PMID: 21276999 Free PMC article.
5,833 results