Silva JL - Search Results

1

Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer.

Silva JL, Cino EA, Soares IN, Ferreira VF, A P de Oliveira G. Silva JL, et al. Acc Chem Res. 2018 Jan 16;51(1):181-190. doi: 10.1021/acs.accounts.7b00473. Epub 2017 Dec 20. Acc Chem Res. 2018. PMID: 29260852 Free article. Review.

2

Fibrillar aggregates of the tumor suppressor p53 core domain.

Ishimaru D, Andrade LR, Teixeira LS, Quesado PA, Maiolino LM, Lopez PM, Cordeiro Y, Costa LT, Heckl WM, Weissmüller G, Foguel D, Silva JL. Ishimaru D, et al. Among authors: silva jl. Biochemistry. 2003 Aug 5;42(30):9022-7. doi: 10.1021/bi034218k. Biochemistry. 2003. PMID: 12885235

3

Conversion of wild-type p53 core domain into a conformation that mimics a hot-spot mutant.

Ishimaru D, Maia LF, Maiolino LM, Quesado PA, Lopez PC, Almeida FC, Valente AP, Silva JL. Ishimaru D, et al. Among authors: silva jl. J Mol Biol. 2003 Oct 17;333(2):443-51. doi: 10.1016/j.jmb.2003.08.026. J Mol Biol. 2003. PMID: 14529628

4

Reversible aggregation plays a crucial role on the folding landscape of p53 core domain.

Ishimaru D, Lima LM, Maia LF, Lopez PM, Ano Bom AP, Valente AP, Silva JL. Ishimaru D, et al. Among authors: silva jl. Biophys J. 2004 Oct;87(4):2691-700. doi: 10.1529/biophysj.104.044685. Epub 2004 Aug 6. Biophys J. 2004. PMID: 15298872 Free PMC article.

5

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

Ishimaru D, Ano Bom AP, Lima LM, Quesado PA, Oyama MF, de Moura Gallo CV, Cordeiro Y, Silva JL. Ishimaru D, et al. Among authors: silva jl. Biochemistry. 2009 Jul 7;48(26):6126-35. doi: 10.1021/bi9003028. Biochemistry. 2009. PMID: 19505151

6

Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins.

Silva JL, Vieira TC, Gomes MP, Bom AP, Lima LM, Freitas MS, Ishimaru D, Cordeiro Y, Foguel D. Silva JL, et al. Acc Chem Res. 2010 Feb 16;43(2):271-9. doi: 10.1021/ar900179t. Acc Chem Res. 2010. PMID: 19817406 Free PMC article. Review.

7

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors.

Levy CB, Stumbo AC, Ano Bom AP, Portari EA, Cordeiro Y, Silva JL, De Moura-Gallo CV. Levy CB, et al. Among authors: silva jl. Int J Biochem Cell Biol. 2011 Jan;43(1):60-4. doi: 10.1016/j.biocel.2010.10.017. Epub 2010 Nov 5. Int J Biochem Cell Biol. 2011. PMID: 21056685

8

Heparin binding by murine recombinant prion protein leads to transient aggregation and formation of RNA-resistant species.

Vieira TC, Reynaldo DP, Gomes MP, Almeida MS, Cordeiro Y, Silva JL. Vieira TC, et al. Among authors: silva jl. J Am Chem Soc. 2011 Jan 19;133(2):334-44. doi: 10.1021/ja106725p. Epub 2010 Dec 13. J Am Chem Soc. 2011. PMID: 21142149

9

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

Ano Bom AP, Rangel LP, Costa DC, de Oliveira GA, Sanches D, Braga CA, Gava LM, Ramos CH, Cepeda AO, Stumbo AC, De Moura Gallo CV, Cordeiro Y, Silva JL. Ano Bom AP, et al. Among authors: silva jl. J Biol Chem. 2012 Aug 10;287(33):28152-62. doi: 10.1074/jbc.M112.340638. Epub 2012 Jun 19. J Biol Chem. 2012. PMID: 22715097 Free PMC article.

10

Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer.

Cordeiro Y, Foguel D, Silva JL. Cordeiro Y, et al. Among authors: silva jl. Biophys Chem. 2013 Dec 15;183:9-18. doi: 10.1016/j.bpc.2013.06.002. Epub 2013 Jun 14. Biophys Chem. 2013. PMID: 23849959 Free article. Review.

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