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Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells.
Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y, Chien S, Chiu JJ. Tsai MC, et al. Among authors: zhou j. Circ Res. 2009 Aug 28;105(5):471-80. doi: 10.1161/CIRCRESAHA.109.193656. Epub 2009 Jul 23. Circ Res. 2009. PMID: 19628794 Free PMC article.
Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.
Lee DY, Li YS, Chang SF, Zhou J, Ho HM, Chiu JJ, Chien S. Lee DY, et al. Among authors: zhou j. J Biol Chem. 2010 Jan 1;285(1):30-42. doi: 10.1074/jbc.M109.010512. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889638 Free PMC article.
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