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Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
McKinnell RM, Fatheree P, Choi SK, Gendron R, Jendza K, Olson Blair B, Budman J, Hill CM, Hegde LG, Yu C, McConn D, Hegde SS, Marquess DG, Klein U. McKinnell RM, et al. Among authors: budman j. ACS Med Chem Lett. 2018 Dec 3;10(1):86-91. doi: 10.1021/acsmedchemlett.8b00462. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655952 Free PMC article.
Topical Reformulation of Valsartan for Treatment of Chronic Diabetic Wounds.
Abadir P, Hosseini S, Faghih M, Ansari A, Lay F, Smith B, Beselman A, Vuong D, Berger A, Tian J, Rini D, Keenahan K, Budman J, Inagami T, Fedarko N, Marti G, Harmon J, Walston J. Abadir P, et al. Among authors: budman j. J Invest Dermatol. 2018 Feb;138(2):434-443. doi: 10.1016/j.jid.2017.09.030. Epub 2017 Oct 24. J Invest Dermatol. 2018. PMID: 29078982 Free PMC article.
Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat.
Hegde LG, Yu C, Renner T, Thibodeaux H, Armstrong SR, Park T, Cheruvu M, Olsufka R, Sandvik ER, Lane CE, Budman J, Hill CM, Klein U, Hegde SS. Hegde LG, et al. Among authors: budman j. J Cardiovasc Pharmacol. 2011 Apr;57(4):495-504. doi: 10.1097/FJC.0b013e318210fc7e. J Cardiovasc Pharmacol. 2011. PMID: 21297495
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