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Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors.
J Med Chem. 2017 Nov 9;60(21):8963-8981. doi: 10.1021/acs.jmedchem.7b01210. Epub 2017 Oct 31.
J Med Chem. 2017.
PMID: 29023121
A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
Yashiro H, Takagahara S, Tamura YO, Miyahisa I, Matsui J, Suzuki H, Ikeda S, Watanabe M.
Yashiro H, et al. Among authors: tamura yo.
PLoS One. 2016 Nov 10;11(11):e0166198. doi: 10.1371/journal.pone.0166198. eCollection 2016.
PLoS One. 2016.
PMID: 27832159
Free PMC article.
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Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model.
Tamura YO, Sugama J, Iwasaki S, Sasaki M, Yasuno H, Aoyama K, Watanabe M, Erion DM, Yashiro H.
Tamura YO, et al.
J Pharmacol Exp Ther. 2021 Nov;379(3):280-289. doi: 10.1124/jpet.121.000786. Epub 2021 Sep 17.
J Pharmacol Exp Ther. 2021.
PMID: 34535562
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Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity.
Tamura YO, Sugama J, Abe SI, Shimizu Y, Hirose H, Watanabe M.
Tamura YO, et al.
Pharmacol Res Perspect. 2023 Feb;11(1):e01043. doi: 10.1002/prp2.1043.
Pharmacol Res Perspect. 2023.
PMID: 36585794
Free PMC article.
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