Al-Khawaja A - Search Results

1

Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).

Jørgensen L, Al-Khawaja A, Kickinger S, Vogensen SB, Skovgaard-Petersen J, Rosenthal E, Borkar N, Löffler R, Madsen KK, Bräuner-Osborne H, Schousboe A, Ecker GF, Wellendorph P, Clausen RP. Jørgensen L, et al. Among authors: al khawaja a. J Med Chem. 2017 Nov 9;60(21):8834-8846. doi: 10.1021/acs.jmedchem.7b00924. Epub 2017 Oct 19. J Med Chem. 2017. PMID: 28991462

2

Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1).

Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie ME, Kragholm B, Bräuner-Osborne H, Clausen RP, Frølund B, Wellendorph P. Al-Khawaja A, et al. Neurochem Res. 2014 Oct;39(10):1988-96. doi: 10.1007/s11064-014-1336-9. Epub 2014 May 23. Neurochem Res. 2014. PMID: 24852577

3

Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3.

Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP. Damgaard M, et al. Among authors: al khawaja a. ACS Chem Neurosci. 2015 Sep 16;6(9):1591-9. doi: 10.1021/acschemneuro.5b00150. Epub 2015 Jul 23. ACS Chem Neurosci. 2015. PMID: 26154082

4

Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements.

Damgaard M, Haugaard AS, Kickinger S, Al-Khawaja A, Lie MEK, Ecker GF, Clausen RP, Frølund B. Damgaard M, et al. Among authors: al khawaja a. Adv Neurobiol. 2017;16:315-332. doi: 10.1007/978-3-319-55769-4_16. Adv Neurobiol. 2017. PMID: 28828618 Review.

5

Pharmacological Characterization of [³H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter.

Al-Khawaja A, Haugaard AS, Marek A, Löffler R, Thiesen L, Santiveri M, Damgaard M, Bundgaard C, Frølund B, Wellendorph P. Al-Khawaja A, et al. ACS Chem Neurosci. 2018 Mar 21;9(3):545-554. doi: 10.1021/acschemneuro.7b00351. Epub 2017 Nov 22. ACS Chem Neurosci. 2018. PMID: 29131576

6

Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors.

Kickinger S, Al-Khawaja A, Haugaard AS, Lie MEK, Bavo F, Löffler R, Damgaard M, Ecker GF, Frølund B, Wellendorph P. Kickinger S, et al. Among authors: al khawaja a. Sci Rep. 2020 Aug 3;10(1):12992. doi: 10.1038/s41598-020-69908-w. Sci Rep. 2020. PMID: 32747622 Free PMC article.

7

Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1.

Kickinger S, Lie MEK, Suemasa A, Al-Khawaja A, Fujiwara K, Watanabe M, Wilhelmsen KS, Falk-Petersen CB, Frølund B, Shuto S, Ecker GF, Wellendorph P. Kickinger S, et al. Among authors: al khawaja a. Front Chem. 2021 Sep 14;9:736457. doi: 10.3389/fchem.2021.736457. eCollection 2021. Front Chem. 2021. PMID: 34595152 Free PMC article.

8

Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α₁β₂δ GABA_A receptors.

Damgaard M, Al-Khawaja A, Nittegaard-Nielsen M, Petersen RF, Wellendorph P, Frølund B. Damgaard M, et al. Among authors: al khawaja a. Eur J Med Chem. 2017 Sep 29;138:300-312. doi: 10.1016/j.ejmech.2017.06.024. Epub 2017 Jun 15. Eur J Med Chem. 2017. PMID: 28683403

9

Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke.

Lie MEK, Al-Khawaja A, Damgaard M, Haugaard AS, Schousboe A, Clarkson AN, Wellendorph P. Lie MEK, et al. Among authors: al khawaja a. Adv Neurobiol. 2017;16:137-167. doi: 10.1007/978-3-319-55769-4_7. Adv Neurobiol. 2017. PMID: 28828609 Review.

10

IR microspectroscopic investigation of the interaction of some losartan salts with human stratum corneum protein and its effect on losartan transdermal permeation.

Mansour RSH, Al Khawaja AY, Hamdan II, Khalil EA. Mansour RSH, et al. Among authors: al khawaja ay. PLoS One. 2023 Jun 15;18(6):e0287267. doi: 10.1371/journal.pone.0287267. eCollection 2023. PLoS One. 2023. PMID: 37319232 Free PMC article.

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