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Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.
Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ní Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS. Karuppiah V, et al. Among authors: johannissen lo. ACS Catal. 2017 Sep 1;7(9):6268-6282. doi: 10.1021/acscatal.7b01924. Epub 2017 Aug 9. ACS Catal. 2017. PMID: 28966840 Free PMC article.
Atomic description of an enzyme reaction dominated by proton tunneling.
Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Sutcliffe MJ, Scrutton NS, Leys D. Masgrau L, et al. Among authors: johannissen lo. Science. 2006 Apr 14;312(5771):237-41. doi: 10.1126/science.1126002. Science. 2006. PMID: 16614214
Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.
Hay S, Pudney C, Hothi P, Johannissen LO, Masgrau L, Pang J, Leys D, Sutcliffe MJ, Scrutton NS. Hay S, et al. Among authors: johannissen lo. Biochem Soc Trans. 2008 Feb;36(Pt 1):16-21. doi: 10.1042/BST0360016. Biochem Soc Trans. 2008. PMID: 18208377 Review.
Coupled motions direct electrons along human microsomal P450 Chains.
Pudney CR, Khara B, Johannissen LO, Scrutton NS. Pudney CR, et al. Among authors: johannissen lo. PLoS Biol. 2011 Dec;9(12):e1001222. doi: 10.1371/journal.pbio.1001222. Epub 2011 Dec 20. PLoS Biol. 2011. PMID: 22205878 Free PMC article.
52 results