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Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.
Santolini I, Celli R, Cannella M, Imbriglio T, Guiducci M, Parisi P, Schubert J, Iacomino M, Zara F, Lerche H; EuroEPINOMICS CoGIE Consortium; Genetic Commission of Italian League Against Epilepsy (LICE); Moyanova S, Ngomba RT, van Luijtelaar G, Battaglia G, Bruno V, Striano P, Nicoletti F. Santolini I, et al. Epilepsia. 2017 Nov;58(11):1993-2001. doi: 10.1111/epi.13898. Epub 2017 Sep 15. Epilepsia. 2017. PMID: 28913875
WAG/Rij rats show a reduced expression of CB₁ receptors in thalamic nuclei and respond to the CB₁ receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges.
van Rijn CM, Gaetani S, Santolini I, Badura A, Gabova A, Fu J, Watanabe M, Cuomo V, van Luijtelaar G, Nicoletti F, Ngomba RT. van Rijn CM, et al. Among authors: santolini i. Epilepsia. 2010 Aug;51(8):1511-21. doi: 10.1111/j.1528-1167.2009.02510.x. Epub 2010 Feb 3. Epilepsia. 2010. PMID: 20132294 Free article.
The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?
Celli R, Santolini I, Guiducci M, van Luijtelaar G, Parisi P, Striano P, Gradini R, Battaglia G, Ngomba RT, Nicoletti F. Celli R, et al. Among authors: santolini i. Curr Neuropharmacol. 2017;15(6):918-925. doi: 10.2174/1570159X15666170309105451. Curr Neuropharmacol. 2017. PMID: 28290248 Free PMC article. Review.
Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission.
Celli R, Wall MJ, Santolini I, Vergassola M, Di Menna L, Mascio G, Cannella M, van Luijtelaar G, Pittaluga A, Ciruela F, Bruno V, Nicoletti F, Ngomba RT. Celli R, et al. Among authors: santolini i. Neuropharmacology. 2020 Nov 1;178:108240. doi: 10.1016/j.neuropharm.2020.108240. Epub 2020 Aug 6. Neuropharmacology. 2020. PMID: 32768418
Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.
Ngomba RT, Santolini I, Biagioni F, Molinaro G, Simonyi A, van Rijn CM, D'Amore V, Mastroiacovo F, Olivieri G, Gradini R, Ferraguti F, Battaglia G, Bruno V, Puliti A, van Luijtelaar G, Nicoletti F. Ngomba RT, et al. Among authors: santolini i. Neuropharmacology. 2011 Jun;60(7-8):1281-91. doi: 10.1016/j.neuropharm.2011.01.007. Epub 2011 Jan 26. Neuropharmacology. 2011. PMID: 21277877
13 results