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Anti-fibrotic Potential of AT2 Receptor Agonists.
Wang Y, Del Borgo M, Lee HW, Baraldi D, Hirmiz B, Gaspari TA, Denton KM, Aguilar MI, Samuel CS, Widdop RE. Wang Y, et al. Front Pharmacol. 2017 Aug 31;8:564. doi: 10.3389/fphar.2017.00564. eCollection 2017. Front Pharmacol. 2017. PMID: 28912715 Free PMC article. Review.
β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
Del Borgo M, Wang Y, Bosnyak S, Khan M, Walters P, Spizzo I, Perlmutter P, Hilliard L, Denton K, Aguilar MI, Widdop RE, Jones ES. Del Borgo M, et al. Among authors: wang y. Clin Sci (Lond). 2015 Sep;129(6):505-13. doi: 10.1042/CS20150077. Epub 2015 May 8. Clin Sci (Lond). 2015. PMID: 26186568
AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.
Chow BSM, Kocan M, Shen M, Wang Y, Han L, Chew JY, Wang C, Bosnyak S, Mirabito-Colafella KM, Barsha G, Wigg B, Johnstone EKM, Hossain MA, Pfleger KDG, Denton KM, Widdop RE, Summers RJ, Bathgate RAD, Hewitson TD, Samuel CS. Chow BSM, et al. Among authors: wang y, wang c. J Am Soc Nephrol. 2019 Nov;30(11):2191-2207. doi: 10.1681/ASN.2019060597. Epub 2019 Sep 11. J Am Soc Nephrol. 2019. PMID: 31511361 Free PMC article.
Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil.
Wang Y, Han L, Shen M, Jones ES, Spizzo I, Walton SL, Denton KM, Gaspari TA, Samuel CS, Widdop RE. Wang Y, et al. ACS Pharmacol Transl Sci. 2020 Jan 23;3(1):76-87. doi: 10.1021/acsptsci.9b00095. eCollection 2020 Feb 14. ACS Pharmacol Transl Sci. 2020. PMID: 32259090 Free PMC article.
Preclinical rodent models of cardiac fibrosis.
Wang Y, Wang M, Samuel CS, Widdop RE. Wang Y, et al. Among authors: wang m. Br J Pharmacol. 2022 Mar;179(5):882-899. doi: 10.1111/bph.15450. Epub 2021 May 10. Br J Pharmacol. 2022. PMID: 33973236 Free article. Review.
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