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CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
Windpassinger C, Piard J, Bonnard C, Alfadhel M, Lim S, Bisteau X, Blouin S, Ali NB, Ng AYJ, Lu H, Tohari S, Talib SZA, van Hul N, Caldez MJ, Van Maldergem L, Yigit G, Kayserili H, Youssef SA, Coppola V, de Bruin A, Tessarollo L, Choi H, Rupp V, Roetzer K, Roschger P, Klaushofer K, Altmüller J, Roy S, Venkatesh B, Ganger R, Grill F, Ben Chehida F, Wollnik B, Altunoglu U, Al Kaissi A, Reversade B, Kaldis P. Windpassinger C, et al. Among authors: coppola v. Am J Hum Genet. 2017 Sep 7;101(3):391-403. doi: 10.1016/j.ajhg.2017.08.003. Am J Hum Genet. 2017. PMID: 28886341 Free PMC article.
Cdk2 knockout mice are viable.
Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. Berthet C, et al. Among authors: coppola v. Curr Biol. 2003 Oct 14;13(20):1775-85. doi: 10.1016/j.cub.2003.09.024. Curr Biol. 2003. PMID: 14561402 Free article.
Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
Gopinathan L, Tan SL, Padmakumar VC, Coppola V, Tessarollo L, Kaldis P. Gopinathan L, et al. Among authors: coppola v. Cancer Res. 2014 Jul 15;74(14):3870-9. doi: 10.1158/0008-5472.CAN-13-3440. Epub 2014 May 6. Cancer Res. 2014. PMID: 24802190 Free PMC article.
Cdk2 catalytic activity is essential for meiotic cell division in vivo.
Chauhan S, Diril MK, Lee JH, Bisteau X, Manoharan V, Adhikari D, Ratnacaram CK, Janela B, Noffke J, Ginhoux F, Coppola V, Liu K, Tessarollo L, Kaldis P. Chauhan S, et al. Among authors: coppola v. Biochem J. 2016 Sep 15;473(18):2783-98. doi: 10.1042/BCJ20160607. Epub 2016 Jul 1. Biochem J. 2016. PMID: 27371320 Free PMC article.
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
Niska-Blakie J, Gopinathan L, Low KN, Kien YL, Goh CMF, Caldez MJ, Pfeiffenberger E, Jones OS, Ong CB, Kurochkin IV, Coppola V, Tessarollo L, Choi H, Kanagasundaram Y, Eisenhaber F, Maurer-Stroh S, Kaldis P. Niska-Blakie J, et al. Among authors: coppola v. Cell Mol Life Sci. 2020 Sep;77(17):3423-3439. doi: 10.1007/s00018-019-03359-z. Epub 2019 Nov 13. Cell Mol Life Sci. 2020. PMID: 31722069 Free PMC article.
Emi2 Is Essential for Mouse Spermatogenesis.
Gopinathan L, Szmyd R, Low D, Diril MK, Chang HY, Coppola V, Liu K, Tessarollo L, Guccione E, van Pelt AMM, Kaldis P. Gopinathan L, et al. Among authors: coppola v. Cell Rep. 2017 Jul 18;20(3):697-708. doi: 10.1016/j.celrep.2017.06.033. Cell Rep. 2017. PMID: 28723571 Free PMC article.
245 results