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HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.
Philip K, Mills TW, Davies J, Chen NY, Karmouty-Quintana H, Luo F, Molina JG, Amione-Guerra J, Sinha N, Guha A, Eltzschig HK, Blackburn MR. Philip K, et al. Among authors: sinha n. FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12. FASEB J. 2017. PMID: 28701304 Free PMC article.
These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Davies, J., Chen, N.-Y., Karmouty-Quintana, H., Luo, F., Molina, J. G., Amione-Guerra, J., Sinha, N., Guha, A., Eltzschig, H. ...
These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Davies, J., Chen, …
Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension.
Chen NY, D Collum S, Luo F, Weng T, Le TT, M Hernandez A, Philip K, Molina JG, Garcia-Morales LJ, Cao Y, Ko TC, Amione-Guerra J, Al-Jabbari O, Bunge RR, Youker K, Bruckner BA, Hamid R, Davies J, Sinha N, Karmouty-Quintana H. Chen NY, et al. Among authors: sinha n. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L238-54. doi: 10.1152/ajplung.00142.2016. Epub 2016 Jun 17. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27317687 Free PMC article.
Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis.
Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, Sun W, Rajadas J, Bollyky PL, Akkanti BH, Jyothula S, Sinha N, Guha A, Karmouty-Quintana H. Collum SD, et al. Among authors: sinha n. Br J Pharmacol. 2017 Oct;174(19):3284-3301. doi: 10.1111/bph.13947. Epub 2017 Aug 17. Br J Pharmacol. 2017. PMID: 28688167 Free PMC article.
Retransplantation Outcomes at a Large Lung Transplantation Program.
Ren D, Kaleekal TS, Graviss EA, Nguyen DT, Sinha N, Goodarzi A, Agboli I, Suarez EE, Loebe M, Scheinin SA, Bruckner BA. Ren D, et al. Among authors: sinha n. Transplant Direct. 2018 Oct 25;4(11):e404. doi: 10.1097/TXD.0000000000000844. eCollection 2018 Nov. Transplant Direct. 2018. PMID: 30534595 Free PMC article.
The ribotoxic stress response drives UV-mediated cell death.
Sinha NK, McKenney C, Yeow ZY, Li JJ, Nam KH, Yaron-Barir TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Regot S, Green R. Sinha NK, et al. Cell. 2024 May 31:S0092-8674(24)00527-0. doi: 10.1016/j.cell.2024.05.018. Online ahead of print. Cell. 2024. PMID: 38843833
1,205 results