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HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.
Philip K, Mills TW, Davies J, Chen NY, Karmouty-Quintana H, Luo F, Molina JG, Amione-Guerra J, Sinha N, Guha A, Eltzschig HK, Blackburn MR. Philip K, et al. Among authors: davies j. FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12. FASEB J. 2017. PMID: 28701304 Free PMC article.
These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Davies, J., Chen, N.-Y., Karmouty-Quintana, H., Luo, F., Molina, J. G., Amione-Guerra, J., Sinha, N., Guha, A., Eltzschig, H. K., …
These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Davies, …
Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis.
Le TT, Karmouty-Quintana H, Melicoff E, Le TT, Weng T, Chen NY, Pedroza M, Zhou Y, Davies J, Philip K, Molina J, Luo F, George AT, Garcia-Morales LJ, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Agarwal SK, Blackburn MR. Le TT, et al. Among authors: davies j. J Immunol. 2014 Oct 1;193(7):3755-68. doi: 10.4049/jimmunol.1302470. Epub 2014 Aug 29. J Immunol. 2014. PMID: 25172494 Free PMC article. Clinical Trial.
Adenosine promotes vascular barrier function in hyperoxic lung injury.
Davies J, Karmouty-Quintana H, Le TT, Chen NY, Weng T, Luo F, Molina J, Moorthy B, Blackburn MR. Davies J, et al. Physiol Rep. 2014 Sep 28;2(9):e12155. doi: 10.14814/phy2.12155. Print 2014 Sep 1. Physiol Rep. 2014. PMID: 25263205 Free PMC article.
Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension.
Karmouty-Quintana H, Philip K, Acero LF, Chen NY, Weng T, Molina JG, Luo F, Davies J, Le NB, Bunge I, Volcik KA, Le TT, Johnston RA, Xia Y, Eltzschig HK, Blackburn MR. Karmouty-Quintana H, et al. Among authors: davies j. FASEB J. 2015 Jan;29(1):50-60. doi: 10.1096/fj.14-260182. Epub 2014 Oct 15. FASEB J. 2015. PMID: 25318478 Free PMC article.
Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension.
Garcia-Morales LJ, Chen NY, Weng T, Luo F, Davies J, Philip K, Volcik KA, Melicoff E, Amione-Guerra J, Bunge RR, Bruckner BA, Loebe M, Eltzschig HK, Pandit LM, Blackburn MR, Karmouty-Quintana H. Garcia-Morales LJ, et al. Among authors: davies j. Am J Respir Cell Mol Biol. 2016 Apr;54(4):574-83. doi: 10.1165/rcmb.2015-0145OC. Am J Respir Cell Mol Biol. 2016. PMID: 26414702 Free PMC article.
Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension.
Chen NY, D Collum S, Luo F, Weng T, Le TT, M Hernandez A, Philip K, Molina JG, Garcia-Morales LJ, Cao Y, Ko TC, Amione-Guerra J, Al-Jabbari O, Bunge RR, Youker K, Bruckner BA, Hamid R, Davies J, Sinha N, Karmouty-Quintana H. Chen NY, et al. Among authors: davies j. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L238-54. doi: 10.1152/ajplung.00142.2016. Epub 2016 Jun 17. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27317687 Free PMC article.
Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis.
Collum SD, Chen NY, Hernandez AM, Hanmandlu A, Sweeney H, Mertens TCJ, Weng T, Luo F, Molina JG, Davies J, Horan IP, Morrell NW, Amione-Guerra J, Al-Jabbari O, Youker K, Sun W, Rajadas J, Bollyky PL, Akkanti BH, Jyothula S, Sinha N, Guha A, Karmouty-Quintana H. Collum SD, et al. Among authors: davies j. Br J Pharmacol. 2017 Oct;174(19):3284-3301. doi: 10.1111/bph.13947. Epub 2017 Aug 17. Br J Pharmacol. 2017. PMID: 28688167 Free PMC article.
Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.
Mertens TCJ, Hanmandlu A, Tu L, Phan C, Collum SD, Chen NY, Weng T, Davies J, Liu C, Eltzschig HK, Jyothula SSK, Rajagopal K, Xia Y, Guha A, Bruckner BA, Blackburn MR, Guignabert C, Karmouty-Quintana H. Mertens TCJ, et al. Among authors: davies j. Front Physiol. 2018 Jun 1;9:555. doi: 10.3389/fphys.2018.00555. eCollection 2018. Front Physiol. 2018. PMID: 29910735 Free PMC article.
7,410 results