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The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.
Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ. Moy JK, et al. Among authors: khoutorsky a. J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3. J Neurosci. 2017. PMID: 28674170 Free PMC article.
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Gkogkas CG, et al. Among authors: khoutorsky a. Nature. 2013 Jan 17;493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21. Nature. 2013. PMID: 23172145 Free PMC article.
Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells.
Ran I, Gkogkas CG, Vasuta C, Tartas M, Khoutorsky A, Laplante I, Parsyan A, Nevarko T, Sonenberg N, Lacaille JC. Ran I, et al. Among authors: khoutorsky a. J Neurosci. 2013 Jan 30;33(5):1872-86. doi: 10.1523/JNEUROSCI.3264-12.2013. J Neurosci. 2013. PMID: 23365227 Free PMC article.
The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.
Sorge RE, LaCroix-Fralish ML, Tuttle AH, Khoutorsky A, Sotocinal SG, Austin JS, Melmed K, Labialle S, Schmidt JV, Wood JN, Naumova AK, Mogil JS. Sorge RE, et al. Among authors: khoutorsky a. Genes Brain Behav. 2013 Jun;12(4):405-13. doi: 10.1111/gbb.12030. Epub 2013 Mar 19. Genes Brain Behav. 2013. PMID: 23433317 Free article.
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.
Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Gkogkas CG, et al. Among authors: khoutorsky a. Cell Rep. 2014 Dec 11;9(5):1742-1755. doi: 10.1016/j.celrep.2014.10.064. Epub 2014 Nov 26. Cell Rep. 2014. PMID: 25466251 Free PMC article.
Translational control of nociception via 4E-binding protein 1.
Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Elife. 2015 Dec 18;4:e12002. doi: 10.7554/eLife.12002. Elife. 2015. PMID: 26678009 Free PMC article.
eIF2α phosphorylation controls thermal nociception.
Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. doi: 10.1073/pnas.1614047113. Epub 2016 Oct 3. Proc Natl Acad Sci U S A. 2016. PMID: 27698114 Free PMC article.
65 results