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Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C. Doveston RG, et al. Among authors: cao q. FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017 Aug 6. FEBS Lett. 2017. PMID: 28640363 Free article.
Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
Guillory X, Wolter M, Leysen S, Neves JF, Kuusk A, Genet S, Somsen B, Morrow JK, Rivers E, van Beek L, Patel J, Goodnow R, Schoenherr H, Fuller N, Cao Q, Doveston RG, Brunsveld L, Arkin MR, Castaldi P, Boyd H, Landrieu I, Chen H, Ottmann C. Guillory X, et al. Among authors: cao q. J Med Chem. 2020 Jul 9;63(13):6694-6707. doi: 10.1021/acs.jmedchem.9b01942. Epub 2020 Jun 23. J Med Chem. 2020. PMID: 32501690 Free PMC article.
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, Cao Q, Castaldi MP, Chen H, Chiarparin E, Carbajo RJ, Code E, Cowan S, Davey PR, Ferguson AD, Fillery S, Fuller NO, Gao N, Hargreaves D, Howard MR, Hu J, Kawatkar A, Kemmitt PD, Leo E, Molina DM, O'Connell N, Petteruti P, Rasmusson T, Raubo P, Rawlins PB, Ricchiuto P, Robb GR, Schenone M, Waring MJ, Zinda M, Fawell S, Wilson DM. McCoull W, et al. Among authors: cao q. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141. doi: 10.1021/acschembio.8b00698. Epub 2018 Oct 17. ACS Chem Biol. 2018. PMID: 30335946
Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
Casás-Selves M, Zhang AX, Dowling JE, Hallén S, Kawatkar A, Pace NJ, Denz CR, Pontz T, Garahdaghi F, Cao Q, Sabirsh A, Thakur K, O'Connell N, Hu J, Cornella-Taracido I, Weerapana E, Zinda M, Goodnow RA Jr, Castaldi MP. Casás-Selves M, et al. Among authors: cao q. ChemMedChem. 2017 Jun 21;12(12):917-924. doi: 10.1002/cmdc.201700028. Epub 2017 Apr 26. ChemMedChem. 2017. PMID: 28371485
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
McCoull W, Abrams RD, Anderson E, Blades K, Barton P, Box M, Burgess J, Byth K, Cao Q, Chuaqui C, Carbajo RJ, Cheung T, Code E, Ferguson AD, Fillery S, Fuller NO, Gangl E, Gao N, Grist M, Hargreaves D, Howard MR, Hu J, Kemmitt PD, Nelson JE, O'Connell N, Prince DB, Raubo P, Rawlins PB, Robb GR, Shi J, Waring MJ, Whittaker D, Wylot M, Zhu X. McCoull W, et al. Among authors: cao q. J Med Chem. 2017 May 25;60(10):4386-4402. doi: 10.1021/acs.jmedchem.7b00359. Epub 2017 May 9. J Med Chem. 2017. PMID: 28485934
Target-based whole-cell screening by ¹H NMR spectroscopy.
Ma J, Cao Q, McLeod SM, Ferguson K, Gao N, Breeze AL, Hu J. Ma J, et al. Among authors: cao q. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4764-7. doi: 10.1002/anie.201410701. Epub 2015 Feb 18. Angew Chem Int Ed Engl. 2015. PMID: 25693499 Free PMC article.
An improved model for fragment-based lead generation at AstraZeneca.
Fuller N, Spadola L, Cowen S, Patel J, Schönherr H, Cao Q, McKenzie A, Edfeldt F, Rabow A, Goodnow R. Fuller N, et al. Among authors: cao q. Drug Discov Today. 2016 Aug;21(8):1272-83. doi: 10.1016/j.drudis.2016.04.023. Epub 2016 May 11. Drug Discov Today. 2016. PMID: 27179986 Review.
4,799 results