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Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.
Pérez-Areales FJ, Betari N, Viayna A, Pont C, Espargaró A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Pérez B, Sabate R, Lamuela-Raventós RM, Andrisano V, Luque FJ, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: de simone a. Future Med Chem. 2017 Jun;9(10):965-981. doi: 10.4155/fmc-2017-0049. Epub 2017 Jun 20. Future Med Chem. 2017. PMID: 28632395
Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.
Naldi M, Fiori J, Pistolozzi M, Drake AF, Bertucci C, Wu R, Mlynarczyk K, Filipek S, De Simone A, Andrisano V. Naldi M, et al. Among authors: de simone a. ACS Chem Neurosci. 2012 Nov 21;3(11):952-62. doi: 10.1021/cn3000982. Epub 2012 Sep 4. ACS Chem Neurosci. 2012. PMID: 23173074 Free PMC article.
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D. Viayna E, et al. Among authors: de simone a. J Med Chem. 2014 Mar 27;57(6):2549-67. doi: 10.1021/jm401824w. Epub 2014 Mar 10. J Med Chem. 2014. PMID: 24568372 Free article.
Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate.
De Simone A, Seidl C, Santos CA, Andrisano V. De Simone A, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:108-14. doi: 10.1016/j.jchromb.2014.01.056. Epub 2014 Feb 11. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24590190
510 results