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Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.
Sampson JH, Archer GE, Ashley DM, Fuchs HE, Hale LP, Dranoff G, Bigner DD. Sampson JH, et al. Among authors: dranoff g. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10399-404. doi: 10.1073/pnas.93.19.10399. Proc Natl Acad Sci U S A. 1996. PMID: 8816812 Free PMC article.
Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.
Sampson JH, Crotty LE, Lee S, Archer GE, Ashley DM, Wikstrand CJ, Hale LP, Small C, Dranoff G, Friedman AH, Friedman HS, Bigner DD. Sampson JH, et al. Among authors: dranoff g. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7503-8. doi: 10.1073/pnas.130166597. Proc Natl Acad Sci U S A. 2000. PMID: 10852962 Free PMC article.
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.
Woroniecka K, Chongsathidkiet P, Rhodin K, Kemeny H, Dechant C, Farber SH, Elsamadicy AA, Cui X, Koyama S, Jackson C, Hansen LJ, Johanns TM, Sanchez-Perez L, Chandramohan V, Yu YA, Bigner DD, Giles A, Healy P, Dranoff G, Weinhold KJ, Dunn GP, Fecci PE. Woroniecka K, et al. Among authors: dranoff g. Clin Cancer Res. 2018 Sep 1;24(17):4175-4186. doi: 10.1158/1078-0432.CCR-17-1846. Epub 2018 Feb 7. Clin Cancer Res. 2018. PMID: 29437767 Free PMC article.
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.
Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC. Dranoff G, et al. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3539-43. doi: 10.1073/pnas.90.8.3539. Proc Natl Acad Sci U S A. 1993. PMID: 8097319 Free PMC article.
221 results