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Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia.
Thakkar N, Guptill JT, Aleš K, Jacobus D, Jacobus L, Peloquin C, Cohen-Wolkowiez M, Gonzalez D; DAPPER Study Group. Thakkar N, et al. Among authors: jacobus d, jacobus l. CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):625-634. doi: 10.1002/psp4.12218. Epub 2017 Jul 24. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28623849 Free PMC article. Clinical Trial.
3,4-diaminopyridine base effectively treats the weakness of Lambert-Eaton myasthenia.
Sanders DB, Juel VC, Harati Y, Smith AG, Peltier AC, Marburger T, Lou JS, Pascuzzi RM, Richman DP, Xie T, Demmel V, Jacobus LR, Aleš KL, Jacobus DP; Dapper Study Team. Sanders DB, et al. Among authors: jacobus dp, jacobus lr. Muscle Nerve. 2018 Apr;57(4):561-568. doi: 10.1002/mus.26052. Epub 2018 Feb 2. Muscle Nerve. 2018. PMID: 29280483 Free PMC article. Clinical Trial.
Validation of the triple timed up-and-go test in Lambert-Eaton myasthenia.
Raja SM, Sanders DB, Juel VC, Harati Y, Smith AG, Pascuzzi R, Richman DP, Wu A, Aleš KL, Jacobus LR, Jacobus DP, Guptill JT; DAPPER Study Team. Raja SM, et al. Among authors: jacobus dp, jacobus lr. Muscle Nerve. 2019 Sep;60(3):292-298. doi: 10.1002/mus.26625. Epub 2019 Jul 18. Muscle Nerve. 2019. PMID: 31269226 Free PMC article.
JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.
Birrell GW, Chavchich M, Ager AL, Shieh HM, Heffernan GD, Zhao W, Krasucki PE, Saionz KW, Terpinski J, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Birrell GW, et al. Among authors: jacobus dp, jacobus lr. Antimicrob Agents Chemother. 2015 Jan;59(1):170-7. doi: 10.1128/AAC.03762-14. Epub 2014 Oct 20. Antimicrob Agents Chemother. 2015. PMID: 25331702 Free PMC article.
Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Chavchich M, Birrell GW, Ager AL, MacKenzie DO, Heffernan GD, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Chavchich M, et al. Among authors: jacobus dp, jacobus lr. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3115-8. doi: 10.1128/AAC.03066-15. Print 2016 May. Antimicrob Agents Chemother. 2016. PMID: 26856849 Free PMC article.
Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention.
Birrell GW, Heffernan GD, Schiehser GA, Anderson J, Ager AL, Morales P, MacKenzie D, van Breda K, Chavchich M, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD. Birrell GW, et al. Among authors: jacobus dp, jacobus lr. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01335-17. doi: 10.1128/AAC.01335-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29311093 Free PMC article.
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