Thakur M - Search Results

1

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.

Gilabert-Oriol R, Furness SGB, Stringer BW, Weng A, Fuchs H, Day BW, Kourakis A, Boyd AW, Hare DL, Thakur M, Johns TG, Wookey PJ. Gilabert-Oriol R, et al. Among authors: thakur m. Cancer Immunol Immunother. 2017 Sep;66(9):1217-1228. doi: 10.1007/s00262-017-2013-z. Epub 2017 May 13. Cancer Immunol Immunother. 2017. PMID: 28501939 Free PMC article.

2

Saponins modulate the intracellular trafficking of protein toxins.

Weng A, Thakur M, von Mallinckrodt B, Beceren-Braun F, Gilabert-Oriol R, Wiesner B, Eichhorst J, Böttger S, Melzig MF, Fuchs H. Weng A, et al. Among authors: thakur m. J Control Release. 2012 Nov 28;164(1):74-86. doi: 10.1016/j.jconrel.2012.10.002. Epub 2012 Oct 10. J Control Release. 2012. PMID: 23063550

3

Real-time analysis of membrane permeabilizing effects of oleanane saponins.

Gilabert-Oriol R, Mergel K, Thakur M, von Mallinckrodt B, Melzig MF, Fuchs H, Weng A. Gilabert-Oriol R, et al. Among authors: thakur m. Bioorg Med Chem. 2013 Apr 15;21(8):2387-2395. doi: 10.1016/j.bmc.2013.01.061. Epub 2013 Feb 8. Bioorg Med Chem. 2013. PMID: 23454223

4

Small structural differences of targeted anti-tumor toxins result in strong variation of protein expression.

Gilabert-Oriol R, Thakur M, Weise C, Dernedde J, von Mallinckrodt B, Fuchs H, Weng A. Gilabert-Oriol R, et al. Among authors: thakur m. Protein Expr Purif. 2013 Sep;91(1):54-60. doi: 10.1016/j.pep.2013.07.004. Epub 2013 Jul 16. Protein Expr Purif. 2013. PMID: 23867360

5

Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells.

Gilabert-Oriol R, Thakur M, von Mallinckrodt B, Hug T, Wiesner B, Eichhorst J, Melzig MF, Fuchs H, Weng A. Gilabert-Oriol R, et al. Among authors: thakur m. Mol Pharm. 2013 Nov 4;10(11):4347-57. doi: 10.1021/mp400444q. Epub 2013 Oct 7. Mol Pharm. 2013. PMID: 24050452

6

Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.

Gilabert-Oriol R, Weng A, Mallinckrodt Bv, Melzig MF, Fuchs H, Thakur M. Gilabert-Oriol R, et al. Among authors: thakur m. Curr Pharm Des. 2014;20(42):6584-643. doi: 10.2174/1381612820666140826153913. Curr Pharm Des. 2014. PMID: 25341935 Free PMC article. Review.

7

Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma.

von Mallinckrodt B, Thakur M, Weng A, Gilabert-Oriol R, Dürkop H, Brenner W, Lukas M, Beindorff N, Melzig MF, Fuchs H. von Mallinckrodt B, et al. Among authors: thakur m. Future Oncol. 2014 Nov;10(14):2161-75. doi: 10.2217/fon.14.164. Future Oncol. 2014. PMID: 25471031

8

Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861.

Gilabert-Oriol R, Weng A, Trautner A, Weise C, Schmid D, Bhargava C, Niesler N, Wookey PJ, Fuchs H, Thakur M. Gilabert-Oriol R, et al. Among authors: thakur m. Biochem Pharmacol. 2015 Oct 1;97(3):247-55. doi: 10.1016/j.bcp.2015.07.040. Epub 2015 Aug 5. Biochem Pharmacol. 2015. PMID: 26253687

9

Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin.

Gilabert-Oriol R, Thakur M, Haussmann K, Niesler N, Bhargava C, Görick C, Fuchs H, Weng A. Gilabert-Oriol R, et al. Among authors: thakur m. Planta Med. 2016 Dec;82(18):1525-1531. doi: 10.1055/s-0042-110495. Epub 2016 Jul 8. Planta Med. 2016. PMID: 27392242

10

The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins.

Weng A, Thakur M, Beceren-Braun F, Bachran D, Bachran C, Riese SB, Jenett-Siems K, Gilabert-Oriol R, Melzig MF, Fuchs H. Weng A, et al. Among authors: thakur m. Mol Oncol. 2012 Jun;6(3):323-32. doi: 10.1016/j.molonc.2012.01.004. Epub 2012 Jan 24. Mol Oncol. 2012. PMID: 22309811 Free PMC article.

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