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CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.
Manic G, Signore M, Sistigu A, Russo G, Corradi F, Siteni S, Musella M, Vitale S, De Angelis ML, Pallocca M, Amoreo CA, Sperati F, Di Franco S, Barresi S, Policicchio E, De Luca G, De Nicola F, Mottolese M, Zeuner A, Fanciulli M, Stassi G, Maugeri-Saccà M, Baiocchi M, Tartaglia M, Vitale I, De Maria R. Manic G, et al. Among authors: mottolese m. Gut. 2018 May;67(5):903-917. doi: 10.1136/gutjnl-2016-312623. Epub 2017 Apr 7. Gut. 2018. PMID: 28389531 Free PMC article.
Cancer stem cells: are they responsible for treatment failure?
Maugeri-Saccà M, Vici P, Di Lauro L, Barba M, Amoreo CA, Gallo E, Mottolese M, De Maria R. Maugeri-Saccà M, et al. Among authors: mottolese m. Future Oncol. 2014 Oct;10(13):2033-44. doi: 10.2217/fon.14.126. Future Oncol. 2014. PMID: 25396775 Review.
DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.
Ronchetti L, Melucci E, De Nicola F, Goeman F, Casini B, Sperati F, Pallocca M, Terrenato I, Pizzuti L, Vici P, Sergi D, Di Lauro L, Amoreo CA, Gallo E, Diodoro MG, Pescarmona E, Vitale I, Barba M, Buglioni S, Mottolese M, Fanciulli M, De Maria R, Maugeri-Saccà M. Ronchetti L, et al. Among authors: mottolese m. Int J Cancer. 2017 Jun 1;140(11):2587-2595. doi: 10.1002/ijc.30668. Epub 2017 Mar 11. Int J Cancer. 2017. PMID: 28233295 Free article.
Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression.
Di Benedetto A, Ercolani C, Mottolese M, Sperati F, Pizzuti L, Vici P, Terrenato I, Shaaban AM, Humphries MP, Di Lauro L, Barba M, Vitale I, Ciliberto G, Speirs V, De Maria R, Maugeri-Saccà M. Di Benedetto A, et al. Among authors: mottolese m. Sci Rep. 2017 Aug 14;7(1):8078. doi: 10.1038/s41598-017-07366-7. Sci Rep. 2017. PMID: 28808232 Free PMC article.
Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer.
Sette G, Salvati V, Mottolese M, Visca P, Gallo E, Fecchi K, Pilozzi E, Duranti E, Policicchio E, Tartaglia M, Milella M, De Maria R, Eramo A. Sette G, et al. Among authors: mottolese m. Cell Death Dis. 2015 Aug 6;6(8):e1850. doi: 10.1038/cddis.2015.217. Cell Death Dis. 2015. PMID: 26247735 Free PMC article.
Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis.
Vici P, Di Benedetto A, Ercolani C, Pizzuti L, Di Lauro L, Sergi D, Sperati F, Terrenato I, Dattilo R, Botti C, Fabi A, Ramieri MT, Mentuccia L, Marinelli C, Iezzi L, Gamucci T, Natoli C, Vitale I, Barba M, Mottolese M, De Maria R, Maugeri-Saccà M. Vici P, et al. Among authors: mottolese m. Oncotarget. 2015 Dec 15;6(40):42773-80. doi: 10.18632/oncotarget.6001. Oncotarget. 2015. PMID: 26544894 Free PMC article.
DNA Damage and Repair Biomarkers in Cervical Cancer Patients Treated with Neoadjuvant Chemotherapy: An Exploratory Analysis.
Vici P, Buglioni S, Sergi D, Pizzuti L, Di Lauro L, Antoniani B, Sperati F, Terrenato I, Carosi M, Gamucci T, Dattilo R, Bartucci M, Vincenzoni C, Mariani L, Vizza E, Sanguineti G, Gadducci A, Vitale I, Barba M, De Maria R, Mottolese M, Maugeri-Saccà M. Vici P, et al. Among authors: mottolese m. PLoS One. 2016 Mar 1;11(3):e0149872. doi: 10.1371/journal.pone.0149872. eCollection 2016. PLoS One. 2016. PMID: 26930412 Free PMC article.
Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer.
Barba M, Vici P, Pizzuti L, Di Lauro L, Sergi D, Di Benedetto A, Ercolani C, Sperati F, Terrenato I, Botti C, Mentuccia L, Iezzi L, Gamucci T, Natoli C, Vitale I, Mottolese M, De Maria R, Maugeri-Saccà M. Barba M, et al. Among authors: mottolese m. BMC Cancer. 2017 Feb 6;17(1):101. doi: 10.1186/s12885-016-3045-z. BMC Cancer. 2017. PMID: 28166748 Free PMC article.
Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy.
Melucci E, Casini B, Ronchetti L, Pizzuti L, Sperati F, Pallocca M, De Nicola F, Goeman F, Gallo E, Amoreo CA, Sergi D, Terrenato I, Vici P, Di Lauro L, Diodoro MG, Pescarmona E, Barba M, Mazzotta M, Mottolese M, Fanciulli M, Ciliberto G, De Maria R, Buglioni S, Maugeri-Saccà M. Melucci E, et al. Among authors: mottolese m. J Transl Med. 2018 Feb 5;16(1):22. doi: 10.1186/s12967-018-1385-y. J Transl Med. 2018. PMID: 29402328 Free PMC article.
243 results