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Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH Jr, Futerman AH. Ben-David O, et al. Among authors: merrill ah jr. J Biol Chem. 2011 Aug 26;286(34):30022-33. doi: 10.1074/jbc.M111.261206. Epub 2011 Jun 24. J Biol Chem. 2011. PMID: 21705317 Free PMC article.
Modulation of ceramide synthase activity via dimerization.
Laviad EL, Kelly S, Merrill AH Jr, Futerman AH. Laviad EL, et al. Among authors: merrill ah jr. J Biol Chem. 2012 Jun 15;287(25):21025-33. doi: 10.1074/jbc.M112.363580. Epub 2012 Apr 26. J Biol Chem. 2012. PMID: 22539345 Free PMC article.
Eleven residues determine the acyl chain specificity of ceramide synthases.
Tidhar R, Zelnik ID, Volpert G, Ben-Dor S, Kelly S, Merrill AH Jr, Futerman AH. Tidhar R, et al. Among authors: merrill ah jr. J Biol Chem. 2018 Jun 22;293(25):9912-9921. doi: 10.1074/jbc.RA118.001936. Epub 2018 Apr 9. J Biol Chem. 2018. PMID: 29632068 Free PMC article.
Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells.
Venkataraman K, Riebeling C, Bodennec J, Riezman H, Allegood JC, Sullards MC, Merrill AH Jr, Futerman AH. Venkataraman K, et al. Among authors: merrill ah jr. J Biol Chem. 2002 Sep 20;277(38):35642-9. doi: 10.1074/jbc.M205211200. Epub 2002 Jun 24. J Biol Chem. 2002. PMID: 12105227 Free article.
276 results