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Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
J Med Chem. 2017 Mar 23;60(6):2383-2400. doi: 10.1021/acs.jmedchem.6b01620. Epub 2017 Mar 10.
J Med Chem. 2017.
PMID: 28230986
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain JF, Bursavich MG, Freeman EA, Hrdlicka LA, Hodgdon HE, Chen T, Costa DE, Harrison BA, Kapadnis S, Murphy DA, Nolan S, Tu Z, Tang C, Burnett DA, Patzke H, Koenig G.
Blain JF, et al. Among authors: hrdlicka la.
Alzheimers Res Ther. 2016 Aug 30;8(1):34. doi: 10.1186/s13195-016-0199-5.
Alzheimers Res Ther. 2016.
PMID: 27572246
Free PMC article.
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Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.
Bursavich MG, Harrison BA, Acharya R, Costa DE, Freeman EA, Hrdlicka LA, Jin H, Kapadnis S, Moffit JS, Murphy D, Nolan SJ, Patzke H, Tang C, Van Voorhies HE, Wen M, Koenig G, Blain JF, Burnett DA.
Bursavich MG, et al. Among authors: hrdlicka la.
J Med Chem. 2021 Oct 14;64(19):14426-14447. doi: 10.1021/acs.jmedchem.1c00904. Epub 2021 Sep 22.
J Med Chem. 2021.
PMID: 34550687
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Generation and Partial Characterization of Rabbit Monoclonal Antibody to Amyloid-β Peptide 1-37 (Aβ37).
Mehta PD, Blain JF, Freeman EA, Patrick BA, Barshatzky M, Hrdlicka LA, Mehta SP, Frackowiak J, Mazur-Kolecka B, Wegiel J, Patzke H, Miller DL.
Mehta PD, et al. Among authors: hrdlicka la.
J Alzheimers Dis. 2017;57(1):135-145. doi: 10.3233/JAD-161207.
J Alzheimers Dis. 2017.
PMID: 28222530
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Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, Freeman E, De Strooper B, Vulsteke V, Scrocchi L, Zetterberg H, Portelius E, Hutter-Paier B, Havas D, Ahlijanian M, Flood D, Leventhal L, Shapiro G, Patzke H, Chesworth R, Koenig G.
Rogers K, et al.
Mol Neurodegener. 2012 Dec 18;7:61. doi: 10.1186/1750-1326-7-61.
Mol Neurodegener. 2012.
PMID: 23249765
Free PMC article.
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Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.
Wu J, Shih HP, Vigont V, Hrdlicka L, Diggins L, Singh C, Mahoney M, Chesworth R, Shapiro G, Zimina O, Chen X, Wu Q, Glushankova L, Ahlijanian M, Koenig G, Mozhayeva GN, Kaznacheyeva E, Bezprozvanny I.
Wu J, et al.
Chem Biol. 2011 Jun 24;18(6):777-93. doi: 10.1016/j.chembiol.2011.04.012.
Chem Biol. 2011.
PMID: 21700213
Free PMC article.
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Alternate functions of the single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm.
Xiao H, Hrdlicka LA, Nambu JR.
Xiao H, et al. Among authors: hrdlicka la.
Mech Dev. 1996 Aug;58(1-2):65-74. doi: 10.1016/s0925-4773(96)00559-x.
Mech Dev. 1996.
PMID: 8887317
Free article.
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