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Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.
J Med Chem. 2017 Mar 23;60(6):2383-2400. doi: 10.1021/acs.jmedchem.6b01620. Epub 2017 Mar 10.
J Med Chem. 2017.
PMID: 28230986
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain JF, Bursavich MG, Freeman EA, Hrdlicka LA, Hodgdon HE, Chen T, Costa DE, Harrison BA, Kapadnis S, Murphy DA, Nolan S, Tu Z, Tang C, Burnett DA, Patzke H, Koenig G.
Blain JF, et al. Among authors: hodgdon he.
Alzheimers Res Ther. 2016 Aug 30;8(1):34. doi: 10.1186/s13195-016-0199-5.
Alzheimers Res Ther. 2016.
PMID: 27572246
Free PMC article.
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Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, Freeman E, De Strooper B, Vulsteke V, Scrocchi L, Zetterberg H, Portelius E, Hutter-Paier B, Havas D, Ahlijanian M, Flood D, Leventhal L, Shapiro G, Patzke H, Chesworth R, Koenig G.
Rogers K, et al.
Mol Neurodegener. 2012 Dec 18;7:61. doi: 10.1186/1750-1326-7-61.
Mol Neurodegener. 2012.
PMID: 23249765
Free PMC article.
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Neuropharmacokinetics of two investigational compounds in rats: divergent temporal profiles in the brain and cerebrospinal fluid.
Tang C, Chen T, Kapadnis S, Hodgdon H, Tao Y, Chen X, Wen M, Costa D, Murphy D, Nolan S, Flood DG, Welty DF, Koenig G.
Tang C, et al.
Biochem Pharmacol. 2014 Oct 15;91(4):543-51. doi: 10.1016/j.bcp.2014.07.023. Epub 2014 Aug 1.
Biochem Pharmacol. 2014.
PMID: 25091561
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Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays.
Stoiljkovic M, Leventhal L, Chen A, Chen T, Driscoll R, Flood D, Hodgdon H, Hurst R, Nagy D, Piser T, Tang C, Townsend M, Tu Z, Bertrand D, Koenig G, Hajós M.
Stoiljkovic M, et al.
Biochem Pharmacol. 2015 Oct 15;97(4):576-589. doi: 10.1016/j.bcp.2015.07.006. Epub 2015 Jul 20.
Biochem Pharmacol. 2015.
PMID: 26206187
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Knockdown resistance allele frequencies in North American head louse (Anoplura: Pediculidae) populations.
Yoon KS, Previte DJ, Hodgdon HE, Poole BC, Kwon DH, El-Ghar GE, Lee SH, Clark JM.
Yoon KS, et al. Among authors: hodgdon he.
J Med Entomol. 2014 Mar;51(2):450-7. doi: 10.1603/me13139.
J Med Entomol. 2014.
PMID: 24724296
Free PMC article.
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Determination of knockdown resistance allele frequencies in global human head louse populations using the serial invasive signal amplification reaction.
Hodgdon HE, Yoon KS, Previte DJ, Kim HJ, Aboelghar GE, Lee SH, Clark JM.
Hodgdon HE, et al.
Pest Manag Sci. 2010 Sep;66(9):1031-40. doi: 10.1002/ps.1979.
Pest Manag Sci. 2010.
PMID: 20564731
Free PMC article.
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