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Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
Gomez L, Massari ME, Vickers T, Freestone G, Vernier W, Ly K, Xu R, McCarrick M, Marrone T, Metz M, Yan YG, Yoder ZW, Lemus R, Broadbent NJ, Barido R, Warren N, Schmelzer K, Neul D, Lee D, Andersen CB, Sebring K, Aertgeerts K, Zhou X, Tabatabaei A, Peters M, Breitenbucher JG. Gomez L, et al. J Med Chem. 2017 Mar 9;60(5):2037-2051. doi: 10.1021/acs.jmedchem.6b01793. Epub 2017 Feb 21. J Med Chem. 2017. PMID: 28165743
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
Dyck B, Branstetter B, Gharbaoui T, Hudson AR, Breitenbucher JG, Gomez L, Botrous I, Marrone T, Barido R, Allerston CK, Cedervall EP, Xu R, Sridhar V, Barker R, Aertgeerts K, Schmelzer K, Neul D, Lee D, Massari ME, Andersen CB, Sebring K, Zhou X, Petroski R, Limberis J, Augustin M, Chun LE, Edwards TE, Peters M, Tabatabaei A. Dyck B, et al. Among authors: gomez l. J Med Chem. 2017 Apr 27;60(8):3472-3483. doi: 10.1021/acs.jmedchem.7b00302. Epub 2017 Apr 13. J Med Chem. 2017. PMID: 28406621
Practical and scalable synthesis of a selective CCK1 receptor antagonist.
Mapes CM, Mani NS, Deng X, Pandit CR, McClure KJ, Pippel MC, Sehon CA, Gomez L, Shinde S, Breitenbucher JG, Jones TK. Mapes CM, et al. Among authors: gomez l. J Org Chem. 2010 Nov 19;75(22):7950-3. doi: 10.1021/jo1017684. Epub 2010 Oct 27. J Org Chem. 2010. PMID: 20977279
SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists.
Gomez L, Hack MD, McClure K, Sehon C, Huang L, Morton M, Li L, Barrett TD, Shankley N, Breitenbucher JG. Gomez L, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6493-8. doi: 10.1016/j.bmcl.2007.09.093. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933530
Azabenzthiazole inhibitors of leukotriene A₄ hydrolase.
Tanis VM, Bacani GM, Blevitt JM, Chrovian CC, Crawford S, De Leon A, Fourie AM, Gomez L, Grice CA, Herman K, Kearney AM, Landry-Bayle AM, Lee-Dutra A, Nelson J, Riley JP, Santillán A Jr, Wiener JJ, Xue X, Young AL. Tanis VM, et al. Among authors: gomez l. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7504-11. doi: 10.1016/j.bmcl.2012.10.036. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23127888
1,662 results