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Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
Gomez L, Massari ME, Vickers T, Freestone G, Vernier W, Ly K, Xu R, McCarrick M, Marrone T, Metz M, Yan YG, Yoder ZW, Lemus R, Broadbent NJ, Barido R, Warren N, Schmelzer K, Neul D, Lee D, Andersen CB, Sebring K, Aertgeerts K, Zhou X, Tabatabaei A, Peters M, Breitenbucher JG. Gomez L, et al. Among authors: breitenbucher jg. J Med Chem. 2017 Mar 9;60(5):2037-2051. doi: 10.1021/acs.jmedchem.6b01793. Epub 2017 Feb 21. J Med Chem. 2017. PMID: 28165743
PDE2 inhibition: potential for the treatment of cognitive disorders.
Gomez L, Breitenbucher JG. Gomez L, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6522-7. doi: 10.1016/j.bmcl.2013.10.014. Epub 2013 Oct 24. Bioorg Med Chem Lett. 2013. PMID: 24189054 Free article. Review.
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
Dyck B, Branstetter B, Gharbaoui T, Hudson AR, Breitenbucher JG, Gomez L, Botrous I, Marrone T, Barido R, Allerston CK, Cedervall EP, Xu R, Sridhar V, Barker R, Aertgeerts K, Schmelzer K, Neul D, Lee D, Massari ME, Andersen CB, Sebring K, Zhou X, Petroski R, Limberis J, Augustin M, Chun LE, Edwards TE, Peters M, Tabatabaei A. Dyck B, et al. Among authors: breitenbucher jg. J Med Chem. 2017 Apr 27;60(8):3472-3483. doi: 10.1021/acs.jmedchem.7b00302. Epub 2017 Apr 13. J Med Chem. 2017. PMID: 28406621
Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties.
Santora VJ, Almos TA, Barido R, Basinger J, Bellows CL, Bookser BC, Breitenbucher JG, Broadbent NJ, Cabebe C, Chai CK, Chen M, Chow S, Chung M, Crickard L, Danks AM, Freestone GC, Gitnick D, Gupta V, Hoffmaster C, Hudson AR, Kaplan AP, Kennedy MR, Lee D, Limberis J, Ly K, Mak CC, Masatsugu B, Morse AC, Na J, Neul D, Nikpur J, Peters M, Petroski RE, Renick J, Sebring K, Sevidal S, Tabatabaei A, Wen J, Yan Y, Yoder ZW, Zook D. Santora VJ, et al. Among authors: breitenbucher jg. J Med Chem. 2018 Jul 26;61(14):6018-6033. doi: 10.1021/acs.jmedchem.8b00372. Epub 2018 Jul 11. J Med Chem. 2018. PMID: 29886732
Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes.
Gomez L, Xu R, Sinko W, Selfridge B, Vernier W, Ly K, Truong R, Metz M, Marrone T, Sebring K, Yan Y, Appleton B, Aertgeerts K, Massari ME, Breitenbucher JG. Gomez L, et al. Among authors: breitenbucher jg. J Med Chem. 2018 Sep 13;61(17):7754-7766. doi: 10.1021/acs.jmedchem.8b00713. Epub 2018 Aug 20. J Med Chem. 2018. PMID: 30070482
Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.
Hudson AR, Santora VJ, Petroski RE, Almos TA, Anderson G, Barido R, Basinger J, Bellows CL, Bookser BC, Broadbent NJ, Cabebe C, Chai CK, Chen M, Chow S, Chung M, Heger L, Danks AM, Freestone GC, Gitnick D, Gupta V, Hoffmaster C, Kaplan AP, Kennedy MR, Lee D, Limberis J, Ly K, Mak CC, Masatsugu B, Morse AC, Na J, Neul D, Nikpur J, Renick J, Sebring K, Sevidal S, Tabatabaei A, Wen J, Xia S, Yan Y, Yoder ZW, Zook D, Peters M, Breitenbucher JG. Hudson AR, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2020 Jul 15;30(14):127214. doi: 10.1016/j.bmcl.2020.127214. Epub 2020 Apr 25. Bioorg Med Chem Lett. 2020. PMID: 32527538
Practical and scalable synthesis of a selective CCK1 receptor antagonist.
Mapes CM, Mani NS, Deng X, Pandit CR, McClure KJ, Pippel MC, Sehon CA, Gomez L, Shinde S, Breitenbucher JG, Jones TK. Mapes CM, et al. Among authors: breitenbucher jg. J Org Chem. 2010 Nov 19;75(22):7950-3. doi: 10.1021/jo1017684. Epub 2010 Oct 27. J Org Chem. 2010. PMID: 20977279
Discovery of a novel series of selective HCN1 blockers.
McClure KJ, Maher M, Wu N, Chaplan SR, Eckert WA 3rd, Lee DH, Wickenden AD, Hermann M, Allison B, Hawryluk N, Breitenbucher JG, Grice CA. McClure KJ, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5197-201. doi: 10.1016/j.bmcl.2011.07.051. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21824780
46 results