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Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Viková J, Collinsová M, Kletvíková E, Buděšínský M, Kaplan V, Žáková L, Veverka V, Hexnerová R, Tarazona Aviñó RJ, Straková J, Selicharová I, Vaněk V, Wright DW, Watson CJ, Turkenburg JP, Brzozowski AM, Jiráček J. Viková J, et al. Among authors: collinsova m. Sci Rep. 2016 Jan 21;6:19431. doi: 10.1038/srep19431. Sci Rep. 2016. PMID: 26792393 Free PMC article.
Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.
Macháčková K, Chrudinová M, Radosavljević J, Potalitsyn P, Křížková K, Fábry M, Selicharová I, Collinsová M, Brzozowski AM, Žáková L, Jiráček J. Macháčková K, et al. Among authors: collinsova m. Biochemistry. 2018 Apr 24;57(16):2373-2382. doi: 10.1021/acs.biochem.7b01260. Epub 2018 Apr 10. Biochemistry. 2018. PMID: 29608283 Free article.
Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.
Záková L, Kletvíková E, Lepšík M, Collinsová M, Watson CJ, Turkenburg JP, Jiráček J, Brzozowski AM. Záková L, et al. Among authors: collinsova m. Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2765-74. doi: 10.1107/S1399004714017775. Epub 2014 Sep 27. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 25286859 Free PMC article.
19 results