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Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.
Lanz TV, Williams SK, Stojic A, Iwantscheff S, Sonner JK, Grabitz C, Becker S, Böhler LI, Mohapatra SR, Sahm F, Küblbeck G, Nakamura T, Funakoshi H, Opitz CA, Wick W, Diem R, Platten M. Lanz TV, et al. Among authors: mohapatra sr. Sci Rep. 2017 Jan 24;7:41271. doi: 10.1038/srep41271. Sci Rep. 2017. PMID: 28117398 Free PMC article.
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Sonner JK, Deumelandt K, Ott M, Thomé CM, Rauschenbach KJ, Schulz S, Munteanu B, Mohapatra S, Adam I, Hofer AC, Feuerer M, Opitz CA, Hopf C, Wick W, Platten M. Sonner JK, et al. Oncoimmunology. 2016 Nov 15;5(12):e1240858. doi: 10.1080/2162402X.2016.1240858. eCollection 2016. Oncoimmunology. 2016. PMID: 28123877 Free PMC article.
Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology.
Sonner JK, Keil M, Falk-Paulsen M, Mishra N, Rehman A, Kramer M, Deumelandt K, Röwe J, Sanghvi K, Wolf L, von Landenberg A, Wolff H, Bharti R, Oezen I, Lanz TV, Wanke F, Tang Y, Brandao I, Mohapatra SR, Epping L, Grill A, Röth R, Niesler B, Meuth SG, Opitz CA, Okun JG, Reinhardt C, Kurschus FC, Wick W, Bode HB, Rosenstiel P, Platten M. Sonner JK, et al. Among authors: mohapatra sr. Nat Commun. 2019 Oct 25;10(1):4877. doi: 10.1038/s41467-019-12776-4. Nat Commun. 2019. PMID: 31653831 Free PMC article.
The therapeutic potential of targeting tryptophan catabolism in cancer.
Opitz CA, Somarribas Patterson LF, Mohapatra SR, Dewi DL, Sadik A, Platten M, Trump S. Opitz CA, et al. Among authors: mohapatra sr. Br J Cancer. 2020 Jan;122(1):30-44. doi: 10.1038/s41416-019-0664-6. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819194 Free PMC article. Review.
Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production.
Mohapatra SR, Sadik A, Sharma S, Poschet G, Gegner HM, Lanz TV, Lucarelli P, Klingmüller U, Platten M, Heiland I, Opitz CA. Mohapatra SR, et al. Front Immunol. 2021 Feb 19;12:590532. doi: 10.3389/fimmu.2021.590532. eCollection 2021. Front Immunol. 2021. PMID: 33679737 Free PMC article.
Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation.
Adam I, Dewi DL, Mooiweer J, Sadik A, Mohapatra SR, Berdel B, Keil M, Sonner JK, Thedieck K, Rose AJ, Platten M, Heiland I, Trump S, Opitz CA. Adam I, et al. Among authors: mohapatra sr. Oncoimmunology. 2018 Sep 5;7(12):e1486353. doi: 10.1080/2162402X.2018.1486353. eCollection 2018. Oncoimmunology. 2018. PMID: 30524887 Free PMC article.
56 results