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Abeta deposition is essential to AD neuropathology.
Estus S, Borchelt D, Kindy MS, Vassar R. Estus S, et al. Among authors: vassar r. J Alzheimers Dis. 2002 Jun;4(3):133-8. doi: 10.3233/jad-2002-4302. J Alzheimers Dis. 2002. PMID: 12226531 No abstract available.
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Oakley H, et al. Among authors: vassar r. J Neurosci. 2006 Oct 4;26(40):10129-40. doi: 10.1523/JNEUROSCI.1202-06.2006. J Neurosci. 2006. PMID: 17021169 Free PMC article.
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. Ma H, et al. Among authors: vassar r. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8167-72. doi: 10.1073/pnas.0609521104. Epub 2007 Apr 30. Proc Natl Acad Sci U S A. 2007. PMID: 17470798 Free PMC article.
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. O'Connor T, et al. Among authors: vassar r. Neuron. 2008 Dec 26;60(6):988-1009. doi: 10.1016/j.neuron.2008.10.047. Neuron. 2008. PMID: 19109907 Free PMC article.
154 results