Handel TM - Search Results

1

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM. Zheng Y, et al. Among authors: handel tm. Nature. 2016 Dec 15;540(7633):458-461. doi: 10.1038/nature20605. Epub 2016 Dec 7. Nature. 2016. PMID: 27926736 Free PMC article.

2

Chemokine: receptor structure, interactions, and antagonism.

Allen SJ, Crown SE, Handel TM. Allen SJ, et al. Among authors: handel tm. Annu Rev Immunol. 2007;25:787-820. doi: 10.1146/annurev.immunol.24.021605.090529. Annu Rev Immunol. 2007. PMID: 17291188 Review.

3

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.

Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Wu B, et al. Among authors: handel tm. Science. 2010 Nov 19;330(6007):1066-71. doi: 10.1126/science.1194396. Epub 2010 Oct 7. Science. 2010. PMID: 20929726 Free PMC article.

4

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.

Salanga CL, Handel TM. Salanga CL, et al. Among authors: handel tm. Exp Cell Res. 2011 Mar 10;317(5):590-601. doi: 10.1016/j.yexcr.2011.01.004. Epub 2011 Jan 9. Exp Cell Res. 2011. PMID: 21223963 Free PMC article. Review.

5

Opportunities for functional selectivity in GPCR antibodies.

Webb DR, Handel TM, Kretz-Rommel A, Stevens RC. Webb DR, et al. Among authors: handel tm. Biochem Pharmacol. 2013 Jan 15;85(2):147-52. doi: 10.1016/j.bcp.2012.08.021. Epub 2012 Sep 10. Biochem Pharmacol. 2013. PMID: 22975405 Free PMC article. Review.

6

Chemokine receptor oligomerization and allostery.

Stephens B, Handel TM. Stephens B, et al. Among authors: handel tm. Prog Mol Biol Transl Sci. 2013;115:375-420. doi: 10.1016/B978-0-12-394587-7.00009-9. Prog Mol Biol Transl Sci. 2013. PMID: 23415099 Free PMC article. Review.

7

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer.

Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM. Kufareva I, et al. Among authors: handel tm. Methods Mol Biol. 2013;1013:93-127. doi: 10.1007/978-1-62703-426-5_7. Methods Mol Biol. 2013. PMID: 23625495 Free PMC article.

8

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. O'Hayre M, et al. Among authors: handel tm. Nat Rev Cancer. 2013 Jun;13(6):412-24. doi: 10.1038/nrc3521. Epub 2013 May 3. Nat Rev Cancer. 2013. PMID: 23640210 Free PMC article. Review.

9

Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery.

Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel TM, Payne RJ, Volkman BF. Ziarek JJ, et al. Among authors: handel tm. ACS Chem Biol. 2013 Sep 20;8(9):1955-63. doi: 10.1021/cb400274z. Epub 2013 Jun 26. ACS Chem Biol. 2013. PMID: 23802178 Free PMC article.

10

A general method for site specific fluorescent labeling of recombinant chemokines.

Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. Kawamura T, et al. Among authors: handel tm. PLoS One. 2014 Jan 28;9(1):e81454. doi: 10.1371/journal.pone.0081454. eCollection 2014. PLoS One. 2014. PMID: 24489642 Free PMC article.

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