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Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β.
Luksch H, Romanowski MJ, Chara O, Tüngler V, Caffarena ER, Heymann MC, Lohse P, Aksentijevich I, Remmers EF, Flecks S, Quoos N, Gramatté J, Petzold C, Hofmann SR, Winkler S, Pessler F, Kallinich T, Ganser G, Nimtz-Talaska A, Baumann U, Runde V, Grimbacher B, Birmelin J, Gahr M, Roesler J, Rösen-Wolff A. Luksch H, et al. Hum Mutat. 2013 Jan;34(1):122-31. doi: 10.1002/humu.22169. Epub 2012 Aug 10. Hum Mutat. 2013. PMID: 22833538
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.
Heymann MC, Winkler S, Luksch H, Flecks S, Franke M, Ruß S, Ozen S, Yilmaz E, Klein C, Kallinich T, Lindemann D, Brenner S, Ganser G, Roesler J, Rösen-Wolff A, Hofmann SR. Heymann MC, et al. Among authors: luksch h. J Immunol. 2014 May 1;192(9):4379-85. doi: 10.4049/jimmunol.1203524. Epub 2014 Apr 4. J Immunol. 2014. PMID: 24706726
STING-associated lung disease in mice relies on T cells but not type I interferon.
Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ. Luksch H, et al. J Allergy Clin Immunol. 2019 Jul;144(1):254-266.e8. doi: 10.1016/j.jaci.2019.01.044. Epub 2019 Feb 14. J Allergy Clin Immunol. 2019. PMID: 30772497 Free PMC article.
106 results