Scuotto M - Search Results

1

Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication.

Scuotto M, Abdelnabi R, Collarile S, Schiraldi C, Delang L, Massa A, Ferla S, Brancale A, Leyssen P, Neyts J, Filosa R. Scuotto M, et al. Bioorg Med Chem. 2017 Jan 1;25(1):327-337. doi: 10.1016/j.bmc.2016.10.037. Epub 2016 Oct 31. Bioorg Med Chem. 2017. PMID: 27856239

2

Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.

Peduto A, Scuotto M, Krauth V, Roviezzo F, Rossi A, Temml V, Esposito V, Stuppner H, Schuster D, D'Agostino B, Schiraldi C, de Rosa M, Werz O, Filosa R. Peduto A, et al. Among authors: scuotto m. Eur J Med Chem. 2017 Feb 15;127:715-726. doi: 10.1016/j.ejmech.2016.10.046. Epub 2016 Oct 22. Eur J Med Chem. 2017. PMID: 27836196

3

The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.

Zappavigna S, Scuotto M, Cossu AM, Ingrosso D, De Rosa M, Schiraldi C, Filosa R, Caraglia M. Zappavigna S, et al. Among authors: scuotto m. J Exp Clin Cancer Res. 2016 Oct 22;35(1):167. doi: 10.1186/s13046-016-0440-x. J Exp Clin Cancer Res. 2016. PMID: 27770821 Free PMC article.

4

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U, Liening S, Weinigel C, Rummler S, Schieferdecker S, Nett M, Peduto A, Collarile S, Scuotto M, Roviezzo F, Spaziano G, de Rosa M, Stuppner H, Schuster D, D'Agostino B, Werz O. Schaible AM, et al. Among authors: scuotto m. Biochem Pharmacol. 2016 Jul 15;112:60-71. doi: 10.1016/j.bcp.2016.04.019. Epub 2016 May 5. Biochem Pharmacol. 2016. PMID: 27157409

5

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

Borbone N, Bucci M, Oliviero G, Morelli E, Amato J, D'Atri V, D'Errico S, Vellecco V, Cirino G, Piccialli G, Fattorusso C, Varra M, Mayol L, Persico M, Scuotto M. Borbone N, et al. Among authors: scuotto m. J Med Chem. 2012 Dec 13;55(23):10716-28. doi: 10.1021/jm301414f. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23126678

6

A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance.

Esposito V, Scuotto M, Capuozzo A, Santamaria R, Varra M, Mayol L, Virgilio A, Galeone A. Esposito V, et al. Among authors: scuotto m. Org Biomol Chem. 2014 Nov 28;12(44):8840-3. doi: 10.1039/c4ob01475h. Epub 2014 Oct 8. Org Biomol Chem. 2014. PMID: 25296283

7

Expanding the potential of G-quadruplex structures: formation of a heterochiral TBA analogue.

Virgilio A, Varra M, Scuotto M, Capuozzo A, Irace C, Mayol L, Esposito V, Galeone A. Virgilio A, et al. Among authors: scuotto m. Chembiochem. 2014 Mar 21;15(5):652-5. doi: 10.1002/cbic.201300775. Epub 2014 Feb 12. Chembiochem. 2014. PMID: 24520055

8

5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.

Virgilio A, Petraccone L, Scuotto M, Vellecco V, Bucci M, Mayol L, Varra M, Esposito V, Galeone A. Virgilio A, et al. Among authors: scuotto m. Chembiochem. 2014 Nov 3;15(16):2427-34. doi: 10.1002/cbic.201402355. Epub 2014 Sep 11. Chembiochem. 2014. PMID: 25214456

9

Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.

Rivieccio E, Tartaglione L, Esposito V, Dell'Aversano C, Koneru PC, Scuotto M, Virgilio A, Mayol L, Kvaratskhelia M, Varra M. Rivieccio E, et al. Among authors: scuotto m. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):351-361. doi: 10.1016/j.bbagen.2018.11.001. Epub 2018 Nov 7. Biochim Biophys Acta Gen Subj. 2019. PMID: 30414444

10

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.

Scuotto M, Rivieccio E, Varone A, Corda D, Bucci M, Vellecco V, Cirino G, Virgilio A, Esposito V, Galeone A, Borbone N, Varra M, Mayol L. Scuotto M, et al. Nucleic Acids Res. 2015 Sep 18;43(16):7702-16. doi: 10.1093/nar/gkv789. Epub 2015 Aug 6. Nucleic Acids Res. 2015. PMID: 26250112 Free PMC article.

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