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Targeted PLK1 suppression through RNA interference mediated by high-fidelity Cas13d mitigates osteosarcoma progression via TGF-β/Smad3 signalling.
Yuan Y, Cao D, Zhang A, Liu Z, Deng Z, Zhang S. Yuan Y, et al. J Cell Mol Med. 2024 May;28(10):e18400. doi: 10.1111/jcmm.18400. J Cell Mol Med. 2024. PMID: 38780513 Free PMC article.
Osteosarcoma is the most common primary bone malignancy in children and adolescents. Overexpression of polo-like kinase 1 (PLK1) is frequent in osteosarcoma and drives disease progression and metastasis, making it a promising therapeutic target. ...
Osteosarcoma is the most common primary bone malignancy in children and adolescents. Overexpression of polo-like kinase 1 (PLK1) is f …
The use of genomic assisted selection could allow early selection among Thoroughbreds and Polo Argentino horses for practicing polo.
Azcona F, Karlau A, Trigo P, Molina A, Demyda-Peyrás S. Azcona F, et al. J Equine Vet Sci. 2024 May 17:105098. doi: 10.1016/j.jevs.2024.105098. Online ahead of print. J Equine Vet Sci. 2024. PMID: 38763367
The Polo Argentino (PA) horse is a recognized breed, developed originally by mixing crossbred and Thoroughbred (TB) horses to play polo. ...Our results suggest that empirical selection in PA has generated an incipient genomic differentiation in discrete traits which …
The Polo Argentino (PA) horse is a recognized breed, developed originally by mixing crossbred and Thoroughbred (TB) horses to play …
Sex differences in 3- to 5-year-old children's motor competence: A pooled cross-sectional analysis of 6241 children.
Martins C, Webster EK, Romo-Perez V, Duncan M, Lemos LF, Staiano A, Okely A, Magistro D, Carlevaro F, Bardid F, Magno F, Nobre G, Estevan I, Mota J, Ning K, Robinson LE, Lenoir M, Quan M, Valentini N, Dehkordi PS, Cross P, Jones R, S Henrique R, Salami S, Chen S, Diao Y, Bandeira PR, Barnett LM. Martins C, et al. Scand J Med Sci Sports. 2024 May;34(5):e14651. doi: 10.1111/sms.14651. Scand J Med Sci Sports. 2024. PMID: 38760918
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