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Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales.
Chem Biol Interact. 2017 Apr 1;267:96-103. doi: 10.1016/j.cbi.2016.10.005. Epub 2016 Oct 3.
Chem Biol Interact. 2017.
PMID: 27712998
Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli.
Secher T, Shima A, Hinsinger K, Cintrat JC, Johannes L, Barbier J, Gillet D, Oswald E.
Secher T, et al. Among authors: hinsinger k.
Antimicrob Agents Chemother. 2015 Aug;59(8):5010-3. doi: 10.1128/AAC.00455-15. Epub 2015 May 18.
Antimicrob Agents Chemother. 2015.
PMID: 25987610
Free PMC article.
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The Emergence of Carbon Isotope Exchange.
Hinsinger K, Pieters G.
Hinsinger K, et al.
Angew Chem Int Ed Engl. 2019 Jul 15;58(29):9678-9680. doi: 10.1002/anie.201905368. Epub 2019 Jun 12.
Angew Chem Int Ed Engl. 2019.
PMID: 31188519
Free PMC article.
Review.
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ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.
McGuigan C, Derudas M, Gonczy B, Hinsinger K, Kandil S, Pertusati F, Serpi M, Snoeck R, Andrei G, Balzarini J, McHugh TD, Maitra A, Akorli E, Evangelopoulos D, Bhakta S.
McGuigan C, et al. Among authors: hinsinger k.
Bioorg Med Chem. 2014 May 1;22(9):2816-24. doi: 10.1016/j.bmc.2014.02.056. Epub 2014 Mar 15.
Bioorg Med Chem. 2014.
PMID: 24690527
Free article.
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PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
Pertusati F, Hinsinger K, Flynn ÁS, Powell N, Tristram A, Balzarini J, McGuigan C.
Pertusati F, et al. Among authors: hinsinger k.
Eur J Med Chem. 2014 May 6;78:259-68. doi: 10.1016/j.ejmech.2014.03.051. Epub 2014 Mar 17.
Eur J Med Chem. 2014.
PMID: 24686012
Free article.
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Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.
McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, Madela K, Meneghesso S, Pertusati F, Serpi M, Slusarczyk M, Chamberlain S, Kolykhalov A, Vernachio J, Vanpouille C, Introini A, Margolis L, Balzarini J.
McGuigan C, et al. Among authors: hinsinger k.
Eur J Med Chem. 2013;70:326-40. doi: 10.1016/j.ejmech.2013.09.047. Epub 2013 Oct 9.
Eur J Med Chem. 2013.
PMID: 24177359
Free PMC article.
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Novel antiviral activity of l-dideoxy bicyclic nucleoside analogues versus vaccinia and measles viruses in vitro.
McGuigan C, Hinsinger K, Farleigh L, Pathirana RN, Bugert JJ.
McGuigan C, et al. Among authors: hinsinger k.
J Med Chem. 2013 Feb 14;56(3):1311-22. doi: 10.1021/jm301778x. Epub 2013 Jan 29.
J Med Chem. 2013.
PMID: 23320521
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