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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer.
Kim J, McMillan E, Kim HS, Venkateswaran N, Makkar G, Rodriguez-Canales J, Villalobos P, Neggers JE, Mendiratta S, Wei S, Landesman Y, Senapedis W, Baloglu E, Chow CB, Frink RE, Gao B, Roth M, Minna JD, Daelemans D, Wistuba II, Posner BA, Scaglioni PP, White MA. Kim J, et al. Among authors: venkateswaran n. Nature. 2016 Oct 6;538(7623):114-117. doi: 10.1038/nature19771. Epub 2016 Sep 28. Nature. 2016. PMID: 27680702 Free PMC article.
Anchorage-independent cell proliferation promoted by fascin's F-actin bundling.
Isogai T, Murali VS, Zhou F, Wang X, Rajendran D, Perez-Castro L, Venkateswaran N, Conacci-Sorrell M, Danuser G. Isogai T, et al. Among authors: venkateswaran n. bioRxiv [Preprint]. 2024 May 4:2024.05.04.592404. doi: 10.1101/2024.05.04.592404. bioRxiv. 2024. PMID: 38746129 Free PMC article. Preprint.
Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis.
Schuster K, Venkateswaran N, Rabellino A, Girard L, Peña-Llopis S, Scaglioni PP. Schuster K, et al. Among authors: venkateswaran n. Mol Cancer Res. 2014 Jun;12(6):912-23. doi: 10.1158/1541-7786.MCR-13-0620-T. Epub 2014 Mar 11. Mol Cancer Res. 2014. PMID: 24618618 Free PMC article.
Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.
Ramadori G, Konstantinidou G, Venkateswaran N, Biscotti T, Morlock L, Galié M, Williams NS, Luchetti M, Santinelli A, Scaglioni PP, Coppari R. Ramadori G, et al. Among authors: venkateswaran n. Cell Metab. 2015 Jan 6;21(1):117-25. doi: 10.1016/j.cmet.2014.11.020. Epub 2014 Dec 18. Cell Metab. 2015. PMID: 25533479 Free PMC article.
Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP. Padanad MS, et al. Among authors: venkateswaran n. Cell Rep. 2016 Aug 9;16(6):1614-1628. doi: 10.1016/j.celrep.2016.07.009. Epub 2016 Jul 28. Cell Rep. 2016. PMID: 27477280 Free PMC article.
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.
Venkateswaran N, Garcia R, Lafita-Navarro MC, Hao YH, Perez-Castro L, Nogueira PAS, Solmonson A, Mender I, Kilgore JA, Fang S, Brown IN, Li L, Parks E, Lopes Dos Santos I, Bhaskar M, Kim J, Jia Y, Lemoff A, Grishin NV, Kinch L, Xu L, Williams NS, Shay JW, DeBerardinis RJ, Zhu H, Conacci-Sorrell M. Venkateswaran N, et al. Nat Commun. 2024 May 20;15(1):4266. doi: 10.1038/s41467-024-47868-3. Nat Commun. 2024. PMID: 38769298 Free PMC article.
MYC leads the way.
Venkateswaran N, Conacci-Sorrell M. Venkateswaran N, et al. Small GTPases. 2020 Mar;11(2):86-94. doi: 10.1080/21541248.2017.1364821. Epub 2017 Nov 25. Small GTPases. 2020. PMID: 29173017 Free PMC article. Review.
Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.
Lafita-Navarro MC, Venkateswaran N, Kilgore JA, Kanji S, Han J, Barnes S, Williams NS, Buszczak M, Burma S, Conacci-Sorrell M. Lafita-Navarro MC, et al. Among authors: venkateswaran n. PLoS Genet. 2020 Nov 17;16(11):e1009117. doi: 10.1371/journal.pgen.1009117. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33201894 Free PMC article.
108 results